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- W2019919251 abstract "Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen. WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches." @default.
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- W2019919251 date "2005-01-01" @default.
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- W2019919251 title "Complex genetics of Wegener granulomatosis" @default.
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- W2019919251 doi "https://doi.org/10.1016/j.autrev.2004.06.003" @default.
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