Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019919687> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2019919687 endingPage "196" @default.
- W2019919687 startingPage "187" @default.
- W2019919687 abstract "O-Hexyl, O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral compound that induces delayed neuropathy in hens. This compound is hydrolyzed by a phosphotriesterase known as HDCPase in hen and rat plasma, liver and brain. We studied the stereospecificity of HDCPase in hen tissues and in human and rabbit plasma employing a chromatographic method for analysis and quantification of HDCP stereoisomers. Hen and human plasma HDCPases were not stereospecific. However, rabbit plasma showed a remarkable stereospecificity to S-(−)-HDCP. High levels of stereospecific HDCPase were found in the particulate fraction of hen liver, where S-(−)-HDCP is hydrolyzed faster than R-(+)-HDCP. However, in hen brain the stereospecificity was found in the soluble fraction, where R-(+)-HDCP is hydrolyzed faster than S-(−)-HDCP. It is concluded that liver particulate fraction must be the main tissue responsible for the HDCP stereospecific biotransformation in hens. In an oral administration, the steroisomer R-(+)-HDCP would survive after passing through the liver and would interact with acetylcholinesterase and neuropathy target esterase in the nervous system." @default.
- W2019919687 created "2016-06-24" @default.
- W2019919687 creator A5023851216 @default.
- W2019919687 creator A5050333703 @default.
- W2019919687 creator A5068999361 @default.
- W2019919687 creator A5070569954 @default.
- W2019919687 creator A5091436252 @default.
- W2019919687 date "1998-01-01" @default.
- W2019919687 modified "2023-09-24" @default.
- W2019919687 title "A stereospecific phosphotriesterase in hen liver and brain" @default.
- W2019919687 cites W1870045856 @default.
- W2019919687 cites W1965876977 @default.
- W2019919687 cites W1975250102 @default.
- W2019919687 cites W1982369690 @default.
- W2019919687 cites W1993596224 @default.
- W2019919687 cites W2000476241 @default.
- W2019919687 cites W2000738194 @default.
- W2019919687 cites W2003218689 @default.
- W2019919687 cites W2008138218 @default.
- W2019919687 cites W2035026059 @default.
- W2019919687 cites W2038889765 @default.
- W2019919687 cites W2064814612 @default.
- W2019919687 cites W2070957568 @default.
- W2019919687 cites W2071847768 @default.
- W2019919687 cites W2072665113 @default.
- W2019919687 cites W2073285481 @default.
- W2019919687 cites W2079136050 @default.
- W2019919687 cites W2080120578 @default.
- W2019919687 cites W2084000678 @default.
- W2019919687 cites W2109615304 @default.
- W2019919687 cites W2324038660 @default.
- W2019919687 doi "https://doi.org/10.1016/s0009-2797(97)00106-3" @default.
- W2019919687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9528689" @default.
- W2019919687 hasPublicationYear "1998" @default.
- W2019919687 type Work @default.
- W2019919687 sameAs 2019919687 @default.
- W2019919687 citedByCount "19" @default.
- W2019919687 countsByYear W20199196872014 @default.
- W2019919687 countsByYear W20199196872017 @default.
- W2019919687 countsByYear W20199196872018 @default.
- W2019919687 countsByYear W20199196872021 @default.
- W2019919687 crossrefType "journal-article" @default.
- W2019919687 hasAuthorship W2019919687A5023851216 @default.
- W2019919687 hasAuthorship W2019919687A5050333703 @default.
- W2019919687 hasAuthorship W2019919687A5068999361 @default.
- W2019919687 hasAuthorship W2019919687A5070569954 @default.
- W2019919687 hasAuthorship W2019919687A5091436252 @default.
- W2019919687 hasConcept C161790260 @default.
- W2019919687 hasConcept C181199279 @default.
- W2019919687 hasConcept C185592680 @default.
- W2019919687 hasConcept C187921627 @default.
- W2019919687 hasConcept C2777261171 @default.
- W2019919687 hasConcept C2778816929 @default.
- W2019919687 hasConcept C55493867 @default.
- W2019919687 hasConcept C94412978 @default.
- W2019919687 hasConceptScore W2019919687C161790260 @default.
- W2019919687 hasConceptScore W2019919687C181199279 @default.
- W2019919687 hasConceptScore W2019919687C185592680 @default.
- W2019919687 hasConceptScore W2019919687C187921627 @default.
- W2019919687 hasConceptScore W2019919687C2777261171 @default.
- W2019919687 hasConceptScore W2019919687C2778816929 @default.
- W2019919687 hasConceptScore W2019919687C55493867 @default.
- W2019919687 hasConceptScore W2019919687C94412978 @default.
- W2019919687 hasIssue "3" @default.
- W2019919687 hasLocation W20199196871 @default.
- W2019919687 hasLocation W20199196872 @default.
- W2019919687 hasOpenAccess W2019919687 @default.
- W2019919687 hasPrimaryLocation W20199196871 @default.
- W2019919687 hasRelatedWork W1970395598 @default.
- W2019919687 hasRelatedWork W2008402871 @default.
- W2019919687 hasRelatedWork W2019694725 @default.
- W2019919687 hasRelatedWork W2043305221 @default.
- W2019919687 hasRelatedWork W2118185959 @default.
- W2019919687 hasRelatedWork W2324335556 @default.
- W2019919687 hasRelatedWork W2395879804 @default.
- W2019919687 hasRelatedWork W2471099212 @default.
- W2019919687 hasRelatedWork W2949912922 @default.
- W2019919687 hasRelatedWork W61572660 @default.
- W2019919687 hasVolume "108" @default.
- W2019919687 isParatext "false" @default.
- W2019919687 isRetracted "false" @default.
- W2019919687 magId "2019919687" @default.
- W2019919687 workType "article" @default.