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• W2019920127 abstract "The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a KATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action. Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline and a serotonin reuptake inhibitor, fluvoxamine as a selective serotonin reuptake inhibitor and maprotiline as a selective noradrenaline reuptake inhibitor, were selected, and the effect of glibenclamide on their antinociceptive activities was assessed in male Swiss mice (25-30 g) using a formalin test. None of the drugs affected acute nociceptive responses during the first phase. Amitriptyline (5, 10 mg/kg), maprotiline (10, 20 mg/kg) and fluvoxamine (20 and 30 mg/kg) effectively inhibited pain induction caused by the second phase of the formalin test. Glibenclamide (5 mg/kg) alone did not alter licking behaviors based on a comparison with the control group. However, the pretreatment of animals with glibenclamide (10 and 15 mg/kg) partially reversed the antinociceptive effects of fluvoxamine but not those of maprotiline. In addition, the highest dose of glibenclamide (15 mg/kg) partially prevented the analgesic effect of amitriptyline. Therefore, it seems that adenosine triphosphate-dependent potassium channels have a major role in the analgesic activity of amitriptyline and fluvoxamine." @default.
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• W2019920127 date "2011-01-01" @default.
• W2019920127 modified "2023-09-27" @default.
• W2019920127 title "Effect of glibenclamide on antinociceptive effects of antidepressants of different classes" @default.
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• W2019920127 doi "https://doi.org/10.1590/s1807-59322011000200023" @default.
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