Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019920149> ?p ?o ?g. }
- W2019920149 endingPage "708" @default.
- W2019920149 startingPage "676" @default.
- W2019920149 abstract "1. This review will explore, from a pharmaceutical industry perspective, the evidence and consequences of transport protein involvement in pharmacokinetic variability and safety of drugs in humans. With the preclinical and clinical evidence available, the transport proteins that are considered to be the most important in respect of pharmacokinetic variability and safety in humans will be highlighted.2. A large number of transport proteins have been identified, at both the genetic and the cellular level, which have been suggested to play some role in the absorption, distribution or elimination of endogenous, xenobiotic or drug substrates.3. The weight of evidence suggests that only a small number of transport proteins need to be routinely considered in the drug-discovery setting driven by the magnitude of their impact on tissue distribution, pharmacokinetic variability and drug–drug interactions.4. For the majority of candidate drugs, an assessment of the role of transporter proteins in their disposition and safety need only be assessed if in vivo properties suggest that active transport is likely to be a significant factor, if transport proteins are implicated in a particular therapeutic target area or if the disposition and safety of a likely co-medication are known to be significantly modulated by transport proteins." @default.
- W2019920149 created "2016-06-24" @default.
- W2019920149 creator A5043328521 @default.
- W2019920149 creator A5061479402 @default.
- W2019920149 date "2008-08-01" @default.
- W2019920149 modified "2023-10-16" @default.
- W2019920149 title "Role of transport proteins in drug discovery and development: a pharmaceutical perspective" @default.
- W2019920149 cites W113805164 @default.
- W2019920149 cites W1484689544 @default.
- W2019920149 cites W1504233060 @default.
- W2019920149 cites W1505376713 @default.
- W2019920149 cites W1548348015 @default.
- W2019920149 cites W1577781821 @default.
- W2019920149 cites W1788032165 @default.
- W2019920149 cites W1807250678 @default.
- W2019920149 cites W1844597293 @default.
- W2019920149 cites W1871508751 @default.
- W2019920149 cites W1967808726 @default.
- W2019920149 cites W1968124824 @default.
- W2019920149 cites W1968808154 @default.
- W2019920149 cites W1969190878 @default.
- W2019920149 cites W1970359870 @default.
- W2019920149 cites W1972859881 @default.
- W2019920149 cites W1973981601 @default.
- W2019920149 cites W1976867680 @default.
- W2019920149 cites W1978032026 @default.
- W2019920149 cites W1979536626 @default.
- W2019920149 cites W1979946819 @default.
- W2019920149 cites W1984017257 @default.
- W2019920149 cites W1985258130 @default.
- W2019920149 cites W1986513453 @default.
- W2019920149 cites W1988914651 @default.
- W2019920149 cites W1989588317 @default.
- W2019920149 cites W1990530914 @default.
- W2019920149 cites W1992094709 @default.
- W2019920149 cites W1993198959 @default.
- W2019920149 cites W1994681746 @default.
- W2019920149 cites W1995296705 @default.
- W2019920149 cites W1996104441 @default.
- W2019920149 cites W1997003352 @default.
- W2019920149 cites W1997696660 @default.
- W2019920149 cites W2002121467 @default.
- W2019920149 cites W2002802826 @default.
- W2019920149 cites W2005518854 @default.
- W2019920149 cites W2008077160 @default.
- W2019920149 cites W2014283537 @default.
- W2019920149 cites W2014565106 @default.
- W2019920149 cites W2015318827 @default.
- W2019920149 cites W2017344894 @default.
- W2019920149 cites W2018217049 @default.
- W2019920149 cites W2019532583 @default.
- W2019920149 cites W2021018323 @default.
- W2019920149 cites W2021759214 @default.
- W2019920149 cites W2022868074 @default.
- W2019920149 cites W2022880217 @default.
- W2019920149 cites W2025233096 @default.
- W2019920149 cites W2026330543 @default.
- W2019920149 cites W2027628757 @default.
- W2019920149 cites W2031896095 @default.
- W2019920149 cites W2032320739 @default.
- W2019920149 cites W2033511358 @default.
- W2019920149 cites W2035696809 @default.
- W2019920149 cites W2039141364 @default.
- W2019920149 cites W2039986849 @default.
- W2019920149 cites W2040718125 @default.
- W2019920149 cites W2041063533 @default.
- W2019920149 cites W2043694845 @default.
- W2019920149 cites W2044814201 @default.
- W2019920149 cites W2048593300 @default.
- W2019920149 cites W2049135632 @default.
- W2019920149 cites W2050372475 @default.
- W2019920149 cites W2050381784 @default.
- W2019920149 cites W2050497622 @default.
- W2019920149 cites W2051009834 @default.
- W2019920149 cites W2051835394 @default.
- W2019920149 cites W2052187559 @default.
- W2019920149 cites W2052888437 @default.
- W2019920149 cites W2052925164 @default.
- W2019920149 cites W2054458932 @default.
- W2019920149 cites W2057754476 @default.
- W2019920149 cites W2059293500 @default.
- W2019920149 cites W2059981792 @default.
- W2019920149 cites W2060634509 @default.
- W2019920149 cites W2060798530 @default.
- W2019920149 cites W2061003736 @default.
- W2019920149 cites W2061752537 @default.
- W2019920149 cites W2066382275 @default.
- W2019920149 cites W2067254007 @default.
- W2019920149 cites W2068406006 @default.
- W2019920149 cites W2069390464 @default.
- W2019920149 cites W2071052390 @default.
- W2019920149 cites W2072451809 @default.
- W2019920149 cites W2073650307 @default.
- W2019920149 cites W2073730215 @default.
- W2019920149 cites W2074862075 @default.
- W2019920149 cites W2076027662 @default.
- W2019920149 cites W2076385318 @default.
- W2019920149 cites W2076491064 @default.