FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019920556> ?p ?o ?g. }

• W2019920556 endingPage "238" @default.
• W2019920556 startingPage "229" @default.
• W2019920556 abstract "The thienopyridines, ticlopidine and PCR 4099, inhibit ex vivo aggregation in response to ADP and other agonists. It has been shown that ticlopidine induces a functional defect in the binding of fibrinogen to its platelet membrane receptor. We have studied the effects on platelet functions of PCR 4099 in rat and in man. The aim of the study was to check the possibility of a direct modification of the fibrinogen binding site on the GB IIb–IIIa complex. Washed platelet suspensions were used for aggregation and fibrinogen binding studies. Platelet lysates were submitted to SDS-polyacrylamide gel electrophoresis, crossed immunoelectrophoresis and immunoprecipitation. We found that administration of PCR 4099 inhibited selectively and irreversibly ADP-induced aggregation. Although the effect of ADP on aggregation was blocked, PCR 4099 did not modify ADP-induced shape change. Only the effects of low concentrations of thrombin on platelet aggregation were inhibited. Fibrinogen binding was dramatically inhibited in rat and in man when platelets were stimulated with ADP and low concentrations of thrombin. At high concentration of thrombin there still remained a part of fibrinogen binding inhibition although aggregation was not impaired. Electrophoretic and immunoelectrophoretic studies showed no difference before and after treatment by PCR 4099. In particular, the GP IIb–IIIa-complex was not dissociated, its electrophoretic mobility was not changed and three monoclonal anticomplex antibodies recognized it in the same manner before and after treatment. We conclude that PCR 4099 selectively inhibits the ADP aggregation pathway and that the inhibition of fibrinogen binding is probably not due to a direct modification of the GP IIb–IIIa complex." @default.
• W2019920556 created "2016-06-24" @default.
• W2019920556 creator A5005081144 @default.
• W2019920556 creator A5014618582 @default.
• W2019920556 creator A5018452732 @default.
• W2019920556 creator A5031269524 @default.
• W2019920556 creator A5035259863 @default.
• W2019920556 creator A5044759029 @default.
• W2019920556 creator A5088441623 @default.
• W2019920556 date "1990-07-01" @default.
• W2019920556 modified "2023-10-17" @default.
• W2019920556 title "The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb–IIIa complex in rat and in man" @default.
• W2019920556 cites W103608791 @default.
• W2019920556 cites W1234014522 @default.
• W2019920556 cites W1556035179 @default.
• W2019920556 cites W1556839259 @default.
• W2019920556 cites W1999561083 @default.
• W2019920556 cites W2001546214 @default.
• W2019920556 cites W2009967151 @default.
• W2019920556 cites W2022780618 @default.
• W2019920556 cites W2038819610 @default.
• W2019920556 cites W2047166809 @default.
• W2019920556 cites W2052700765 @default.
• W2019920556 cites W2076060130 @default.
• W2019920556 cites W2085676297 @default.
• W2019920556 cites W2088371504 @default.
• W2019920556 cites W2100837269 @default.
• W2019920556 cites W2150131232 @default.
• W2019920556 cites W2155389142 @default.
• W2019920556 cites W2162469239 @default.
• W2019920556 cites W2235072774 @default.
• W2019920556 cites W2414762872 @default.
• W2019920556 cites W2468277862 @default.
• W2019920556 cites W246850710 @default.
• W2019920556 cites W4239882846 @default.
• W2019920556 doi "https://doi.org/10.1016/0006-2952(90)90683-c" @default.
• W2019920556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2375765" @default.
• W2019920556 hasPublicationYear "1990" @default.
• W2019920556 type Work @default.
• W2019920556 sameAs 2019920556 @default.
• W2019920556 citedByCount "65" @default.
• W2019920556 countsByYear W20199205562013 @default.
• W2019920556 countsByYear W20199205562014 @default.
• W2019920556 countsByYear W20199205562017 @default.
• W2019920556 countsByYear W20199205562019 @default.
• W2019920556 countsByYear W20199205562022 @default.
• W2019920556 crossrefType "journal-article" @default.
• W2019920556 hasAuthorship W2019920556A5005081144 @default.
• W2019920556 hasAuthorship W2019920556A5014618582 @default.
• W2019920556 hasAuthorship W2019920556A5018452732 @default.
• W2019920556 hasAuthorship W2019920556A5031269524 @default.
• W2019920556 hasAuthorship W2019920556A5035259863 @default.
• W2019920556 hasAuthorship W2019920556A5044759029 @default.
• W2019920556 hasAuthorship W2019920556A5088441623 @default.
• W2019920556 hasConcept C107824862 @default.
• W2019920556 hasConcept C12554922 @default.
• W2019920556 hasConcept C153911025 @default.
• W2019920556 hasConcept C185592680 @default.
• W2019920556 hasConcept C203014093 @default.
• W2019920556 hasConcept C2777292125 @default.
• W2019920556 hasConcept C2779036427 @default.
• W2019920556 hasConcept C55493867 @default.
• W2019920556 hasConcept C86803240 @default.
• W2019920556 hasConcept C89560881 @default.
• W2019920556 hasConceptScore W2019920556C107824862 @default.
• W2019920556 hasConceptScore W2019920556C12554922 @default.
• W2019920556 hasConceptScore W2019920556C153911025 @default.
• W2019920556 hasConceptScore W2019920556C185592680 @default.
• W2019920556 hasConceptScore W2019920556C203014093 @default.
• W2019920556 hasConceptScore W2019920556C2777292125 @default.
• W2019920556 hasConceptScore W2019920556C2779036427 @default.
• W2019920556 hasConceptScore W2019920556C55493867 @default.
• W2019920556 hasConceptScore W2019920556C86803240 @default.
• W2019920556 hasConceptScore W2019920556C89560881 @default.
• W2019920556 hasIssue "2" @default.
• W2019920556 hasLocation W20199205561 @default.
• W2019920556 hasLocation W20199205562 @default.
• W2019920556 hasOpenAccess W2019920556 @default.
• W2019920556 hasPrimaryLocation W20199205561 @default.
• W2019920556 hasRelatedWork W1490975006 @default.
• W2019920556 hasRelatedWork W1965032919 @default.
• W2019920556 hasRelatedWork W2055040327 @default.
• W2019920556 hasRelatedWork W2072171268 @default.
• W2019920556 hasRelatedWork W2313435602 @default.
• W2019920556 hasRelatedWork W2406642749 @default.
• W2019920556 hasRelatedWork W2413494355 @default.
• W2019920556 hasRelatedWork W2414762872 @default.
• W2019920556 hasRelatedWork W2466135847 @default.
• W2019920556 hasRelatedWork W4321258383 @default.
• W2019920556 hasVolume "40" @default.
• W2019920556 isParatext "false" @default.
• W2019920556 isRetracted "false" @default.
• W2019920556 magId "2019920556" @default.
• W2019920556 workType "article" @default.