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• W2019920591 abstract "Early phases of Parkinson's disease (PD) are characterized by a mild reduction of dopamine (DA) in striatum and by emergence of psychiatric disturbances that precede overt motor symptoms. In order to characterize the neurochemical re-arrangements induced by such striatal impairment, we used a mouse model in which a low dose of 6-hydroxydopamine (6-OHDA) was bilaterally injected into the dorsal striatum. These mice showed a DA reduction of about 40% that remained stable up to 12 weeks after injection. This reduction was accompanied by changes in DA metabolite levels, such as HVA, transiently reduced at 4 weeks, and DOPAC, decreased at 12 weeks. No change in the 5-hydroxytryptamine (5-HT) levels was found but the 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio was increased at 4 weeks. In addition, at the same time-point, the levels of 15-F2t-IsoP, an index of oxidative stress, and of PGE2, a major product of cyclooxygenase-2, were decreased in different brain areas while BDNF levels were increased. These neurochemical changes were accompanied by altered behavioral responses concerning the emotional reactivity. Overall, the present findings suggest that a change of 5-HT metabolism and a modification of oxidative stress levels may play a role in the early PD degeneration phases." @default.
• W2019920591 created "2016-06-24" @default.
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• W2019920591 date "2010-03-01" @default.
• W2019920591 modified "2023-10-17" @default.
• W2019920591 title "Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease" @default.
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• W2019920591 doi "https://doi.org/10.1016/j.bbr.2009.11.020" @default.
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