FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019920745> ?p ?o ?g. }

• W2019920745 endingPage "752" @default.
• W2019920745 startingPage "743" @default.
• W2019920745 abstract "Non-invasive PET imaging with radiolabeled RGD peptides for α(v)β(3) integrin targeting has become an important tool for tumor diagnosis and treatment monitoring in both pre-clinical and clinical studies. To better understand the molecular process and tracer pharmacokinetics, we introduced kinetic modeling in the investigation of (18)F-labeled RGD peptide monomer (18)F-FP-c(RGDyK) (denoted as (18)F-FPRGD) and dimer (18)F-FP-PEG3-E[c(RGDyK)](2) (denoted as (18)F-FPPRGD2).MDA-MB-435 tumor-bearing mice underwent 60 min dynamic PET scans following the injection of either (18)F-FPRGD or (18)F-FPPRGD2. Blocking studies with pre-injection of a blocking mass dose were performed for both monomeric and dimeric RGD groups. (18)F-FPRAD (RAD) was used as a negative control. Kinetic parameters (K(1), k(2), k(3), k(4)) of a three-compartment model were fitted to the dynamic data to allow quantitative comparisons between the monomeric and dimeric RGD peptides.Dimeric RGD peptide tracer showed significantly higher binding potential (Bp(ND) = k(3)/k(4), 5.87 ± 0.31) than that of the monomeric analog (2.75 ± 0.48, p = 0.0022, n = 4/group). The Bp(ND) values showed a significantly greater ratio (dimer/monomer ~2.1) than the difference in %ID/g uptake measured from static images (dimer/monomer ~1.5, p = 0.0045). Significant decrease in Bp(ND) was found in the blocked groups compared with the unblocked ones (dimer p = 0.00024, monomer p = 0.005, n = 4/group). Similarly, the RAD control group showed the lowest Bp(ND) value among all the test groups, as the RAD peptide does not bind to integrin α(v)β(3). Volume of distribution (V(T) = K(1)/k (2)(1 + k (3)/k (4))) could be separated into non-specific (V (ND) = K (1)/k (2)) and specific (V (S) = K (1) k (3)/(k (2) k (4))) components. Specific distribution volume (V(S)) was the dominant component of V(T) in the unblocked groups and decreased in the blocked groups. Unblocked RGD dimer also showed higher V(S) than that of the monomer (dimer V(S) = 2.38 ± 0.15, monomer V(S) = 0.90 ± 0.17, p = 0.0013, n = 4/group), well correlated with Bp(ND) calculations. Little difference in V(ND) was found among all groups. Moreover, parametric maps allowed quantitative analysis at voxel level and provided higher tumor-to-background contrast for Bp(ND) maps than the static images. Tumor heterogeneity in kinetic parameters was found in parametric images, which could not be clearly identified in static intensity images.The pharmacokinetics of both monomeric and dimeric RGD peptide tracers was compared, and the RGD dimers showed significantly higher binding affinity than the monomeric analogs. Kinetic parameters were demonstrated to be valuable for separating specific and non-specific binding and may allow more sensitive and detailed quantification than simple standardized uptake value analysis." @default.
• W2019920745 created "2016-06-24" @default.
• W2019920745 creator A5006566087 @default.
• W2019920745 creator A5018249388 @default.
• W2019920745 creator A5039085563 @default.
• W2019920745 creator A5042292877 @default.
• W2019920745 creator A5053254472 @default.
• W2019920745 creator A5088055918 @default.
• W2019920745 creator A5089833045 @default.
• W2019920745 date "2012-03-22" @default.
• W2019920745 modified "2023-10-16" @default.
• W2019920745 title "Quantitative Analysis and Parametric Imaging of 18F-Labeled Monomeric and Dimeric RGD Peptides Using Compartment Model" @default.
• W2019920745 cites W1969391202 @default.
• W2019920745 cites W1971093463 @default.
• W2019920745 cites W2004528192 @default.
• W2019920745 cites W2009510043 @default.
• W2019920745 cites W2016918536 @default.
• W2019920745 cites W2017818795 @default.
• W2019920745 cites W2024595947 @default.
• W2019920745 cites W2027763951 @default.
• W2019920745 cites W2028202722 @default.
• W2019920745 cites W2031464563 @default.
• W2019920745 cites W2048598450 @default.
• W2019920745 cites W2051995363 @default.
• W2019920745 cites W2083916521 @default.
• W2019920745 cites W2090203522 @default.
• W2019920745 cites W2094348788 @default.
• W2019920745 cites W2105466461 @default.
• W2019920745 cites W2108713158 @default.
• W2019920745 cites W2112278807 @default.
• W2019920745 cites W2118265724 @default.
• W2019920745 cites W2124114323 @default.
• W2019920745 cites W2136209423 @default.
• W2019920745 cites W2142635246 @default.
• W2019920745 cites W2152450078 @default.
• W2019920745 cites W2153771484 @default.
• W2019920745 cites W2159606669 @default.
• W2019920745 cites W2162637355 @default.
• W2019920745 cites W2164079069 @default.
• W2019920745 cites W2169382529 @default.
• W2019920745 cites W2335752216 @default.
• W2019920745 cites W2461642981 @default.
• W2019920745 doi "https://doi.org/10.1007/s11307-012-0541-7" @default.
• W2019920745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3401513" @default.
• W2019920745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22437879" @default.
• W2019920745 hasPublicationYear "2012" @default.
• W2019920745 type Work @default.
• W2019920745 sameAs 2019920745 @default.
• W2019920745 citedByCount "24" @default.
• W2019920745 countsByYear W20199207452012 @default.
• W2019920745 countsByYear W20199207452013 @default.
• W2019920745 countsByYear W20199207452014 @default.
• W2019920745 countsByYear W20199207452015 @default.
• W2019920745 countsByYear W20199207452016 @default.
• W2019920745 countsByYear W20199207452018 @default.
• W2019920745 countsByYear W20199207452019 @default.
• W2019920745 countsByYear W20199207452021 @default.
• W2019920745 countsByYear W20199207452022 @default.
• W2019920745 countsByYear W20199207452023 @default.
• W2019920745 crossrefType "journal-article" @default.
• W2019920745 hasAuthorship W2019920745A5006566087 @default.
• W2019920745 hasAuthorship W2019920745A5018249388 @default.
• W2019920745 hasAuthorship W2019920745A5039085563 @default.
• W2019920745 hasAuthorship W2019920745A5042292877 @default.
• W2019920745 hasAuthorship W2019920745A5053254472 @default.
• W2019920745 hasAuthorship W2019920745A5088055918 @default.
• W2019920745 hasAuthorship W2019920745A5089833045 @default.
• W2019920745 hasBestOaLocation W20199207452 @default.
• W2019920745 hasConcept C112705442 @default.
• W2019920745 hasConcept C166940927 @default.
• W2019920745 hasConcept C178790620 @default.
• W2019920745 hasConcept C185592680 @default.
• W2019920745 hasConcept C2779281246 @default.
• W2019920745 hasConcept C2779546866 @default.
• W2019920745 hasConcept C521977710 @default.
• W2019920745 hasConcept C55493867 @default.
• W2019920745 hasConcept C71240020 @default.
• W2019920745 hasConcept C71924100 @default.
• W2019920745 hasConcept C98274493 @default.
• W2019920745 hasConceptScore W2019920745C112705442 @default.
• W2019920745 hasConceptScore W2019920745C166940927 @default.
• W2019920745 hasConceptScore W2019920745C178790620 @default.
• W2019920745 hasConceptScore W2019920745C185592680 @default.
• W2019920745 hasConceptScore W2019920745C2779281246 @default.
• W2019920745 hasConceptScore W2019920745C2779546866 @default.
• W2019920745 hasConceptScore W2019920745C521977710 @default.
• W2019920745 hasConceptScore W2019920745C55493867 @default.
• W2019920745 hasConceptScore W2019920745C71240020 @default.
• W2019920745 hasConceptScore W2019920745C71924100 @default.
• W2019920745 hasConceptScore W2019920745C98274493 @default.
• W2019920745 hasIssue "6" @default.
• W2019920745 hasLocation W20199207451 @default.
• W2019920745 hasLocation W20199207452 @default.
• W2019920745 hasLocation W20199207453 @default.
• W2019920745 hasLocation W20199207454 @default.
• W2019920745 hasOpenAccess W2019920745 @default.
• W2019920745 hasPrimaryLocation W20199207451 @default.
• W2019920745 hasRelatedWork W1972220625 @default.

• next