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- W2019921405 abstract "The regeneration of skeletal muscles involves satellite cells, which are muscle-specific precursor cells. In muscles, injured either mechanically or as a consequence of a disease, such as muscular dystrophy, local release of the growth factors and cytokines leads to satellite cells activation, proliferation and differentiation of the resulting myoblasts, followed by the formation of new myofibres. Various cell types, such as stem and progenitor cells, originating from other tissues different than the muscle, are also able to follow a myogenic program. Participation of these cells in the repair process depends on their precise mobilisation to the site of the injury.In this study, we showed that stromal-derived factor-1 (Sdf-1) impacts on the mobilisation of CXC chemokine receptor (Cxcr)4-positive cells and improves skeletal muscle regeneration. Analysis of isolated and in vitro cultured satellite cells showed that Sdf-1 did not influence myoblasts proliferation and expression of myogenic regulatory transcription factors but induced migration of the myoblasts in Cxcr4-dependent ways. This phenomenon was also associated with the increased activity of crucial extracellular matrix modifiers, i.e. metalloproteases Mmp-2 and Mmp-9.Thus, positive impact of Sdf-1 on muscle regeneration is related to the mobilisation of endogenous cells, that is satellite cells and myoblasts, as well as non-muscle stem cells, expressing Cxcr4 and CD34." @default.
- W2019921405 created "2016-06-24" @default.
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- W2019921405 date "2012-11-02" @default.
- W2019921405 modified "2023-10-05" @default.
- W2019921405 title "Sdf-1 (CXCL12) improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells" @default.
- W2019921405 cites W146461824 @default.
- W2019921405 cites W1570160369 @default.
- W2019921405 cites W1577577364 @default.
- W2019921405 cites W1966786218 @default.
- W2019921405 cites W1969986792 @default.
- W2019921405 cites W1971614569 @default.
- W2019921405 cites W1972984824 @default.
- W2019921405 cites W1974631564 @default.
- W2019921405 cites W1979983097 @default.
- W2019921405 cites W1981141119 @default.
- W2019921405 cites W1981426060 @default.
- W2019921405 cites W1984974003 @default.
- W2019921405 cites W1985278214 @default.
- W2019921405 cites W1991380378 @default.
- W2019921405 cites W1993691696 @default.
- W2019921405 cites W1993902386 @default.
- W2019921405 cites W1999126087 @default.
- W2019921405 cites W2002225939 @default.
- W2019921405 cites W2003816645 @default.
- W2019921405 cites W2005975965 @default.
- W2019921405 cites W2006773314 @default.
- W2019921405 cites W2013621644 @default.
- W2019921405 cites W2016009760 @default.
- W2019921405 cites W2036021001 @default.
- W2019921405 cites W2041272135 @default.
- W2019921405 cites W2043126651 @default.
- W2019921405 cites W2045742275 @default.
- W2019921405 cites W2048354593 @default.
- W2019921405 cites W2049736461 @default.
- W2019921405 cites W2051298035 @default.
- W2019921405 cites W2055665660 @default.
- W2019921405 cites W2056281268 @default.
- W2019921405 cites W2058645796 @default.
- W2019921405 cites W2059053280 @default.
- W2019921405 cites W2060092038 @default.
- W2019921405 cites W2060773885 @default.
- W2019921405 cites W2063575819 @default.
- W2019921405 cites W2067115133 @default.
- W2019921405 cites W2067657178 @default.
- W2019921405 cites W2083405476 @default.
- W2019921405 cites W2089748634 @default.
- W2019921405 cites W2091545998 @default.
- W2019921405 cites W2091647214 @default.
- W2019921405 cites W2092013190 @default.
- W2019921405 cites W2092517434 @default.
- W2019921405 cites W2097925286 @default.
- W2019921405 cites W2098636563 @default.
- W2019921405 cites W2101461932 @default.
- W2019921405 cites W2103417302 @default.
- W2019921405 cites W2105840074 @default.
- W2019921405 cites W2107259575 @default.
- W2019921405 cites W2112371560 @default.
- W2019921405 cites W2113561239 @default.
- W2019921405 cites W2116059256 @default.
- W2019921405 cites W2116489844 @default.
- W2019921405 cites W2119473877 @default.
- W2019921405 cites W2123643395 @default.
- W2019921405 cites W2131847752 @default.
- W2019921405 cites W2133496200 @default.
- W2019921405 cites W2136918383 @default.
- W2019921405 cites W2150395635 @default.
- W2019921405 cites W2157467277 @default.
- W2019921405 cites W2157742358 @default.
- W2019921405 cites W2165276410 @default.
- W2019921405 cites W2169584423 @default.
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- W2019921405 doi "https://doi.org/10.1111/boc.201200022" @default.
- W2019921405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22978573" @default.
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