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• W2019921540 abstract "T HE CONCEPT OF USING antibacterial agents to prevent infectious endocarditis (IE) was proposed more than 60 years ago and was first endorsed by the American Heart Association (AHA) in its recommendations for IE prophylaxis published in 1955. Since that time, IE prophylaxis has become a widely accepted preventive measure, broadly endorsed by a number of international professional societies, representingcardiologists, gastroenterologists, infectious diseases specialists, dentists, and pediatricians. Like other rare illnesses, IE is difficult to study, and firm evidence establishing the benefit of prophylaxis has been elusive. Indeed, studies suggesting that IE prophylaxis is ineffective and carries a risk of adverse drug events, and increased bacterial resistance has prompted calls to revise the AHA recommendations and scale back its use. However, IE prophylaxis has become engrained in the minds of physicians, dentists, and their patients, and, although not its intent, the AHA recommendations for IE prophylaxis have become a clinical standard of care. In the absence of definitive data, what should the practicing clinician do? In this article, I will review the rationale for IE prophylaxis. Although the evidence is not based on randomized clinical trial data, I will argue that the evidence is robust and compelling, and more than sufficient to support the continued use of IE prophylaxis in clinical practice." @default.
• W2019921540 created "2016-06-24" @default.
• W2019921540 creator A5025198443 @default.
• W2019921540 date "2007-02-26" @default.
• W2019921540 modified "2023-09-30" @default.
• W2019921540 title "The Case for Infectious Endocarditis Prophylaxis" @default.
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• W2019921540 doi "https://doi.org/10.1001/archinte.167.4.327" @default.
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