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- W2019921809 abstract "Abstract 17β-Estradiol-6, 7-3H-17-glucosiduronate was injected intravenously into 2 normal young females. In one, 17β-estradiol-4-14C was simultaneously administered by the same route. Most of the 3H was excreted in 48 hr., the main urinary metabolites being estrone and 17β-estradiol which were liberated from conjugation by β-glucuronidase hydrolysis. These 2 steroids occurred in a ratio of about 1:1 and accounted for more than 80% of identified 3H-metabolites. Estriol accounted for only 3% and other 16-oxygenated metabolites were of minor quantitative significance as was 2-methoxyestrone. Smaller amounts of each steroid were liberated from conjugation by solvolysis after β-glucuronidase incubation. When 17β-estradiol-4-14C was administered along with the glucosiduronate, urinary 2-methoxyestrone, estrone and 17β-estradiol ‘glucosiduronates’ were produced to a greater extent from the injected conjugate than from the free steroid. This was also true of 17β-estradiol liberated by solvolysis. 2-Methoxyestrone and estrone liberated by solvolysis had 3H/14C ratios similar to that injected whereas all of the 16-oxygenated metabolites, regardless of conjugation, were formed preferentially from injected 17β-estradiol." @default.
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- W2019921809 modified "2023-10-18" @default.
- W2019921809 title "Metabolism of 17β-estradiol-6, 7-3H-17-glucosiduronate by the human female" @default.
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- W2019921809 doi "https://doi.org/10.1016/s0039-128x(69)80021-8" @default.
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