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- W2019922908 abstract "Significance Several therapeutic strategies have been used to enhance monoamine neurotransmitter signaling. However, many of these interventions have deleterious side effects or lose effectiveness due to off-target actions and system feedback. These undesirable consequences likely occur because of temporal dysregulation of neurotransmitter release and uptake. We demonstrate that increasing vesicular packaging enhances dopamine neurotransmission without this signaling disruption. Mice with elevated vesicular monoamine transporter display increased dopamine release, improved outcomes on anxiety and depressive behaviors, enhanced locomotion, and protection from a Parkinson disease-related neurotoxic insult. The malleable nature of the dopamine vesicle suggests that interventions aimed at enhancing vesicle filling may be of therapeutic benefit." @default.
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- W2019922908 date "2014-06-16" @default.
- W2019922908 modified "2023-10-14" @default.
- W2019922908 title "Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo" @default.
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- W2019922908 doi "https://doi.org/10.1073/pnas.1402134111" @default.
- W2019922908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4103325" @default.
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