Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019923555> ?p ?o ?g. }
- W2019923555 endingPage "1207" @default.
- W2019923555 startingPage "1192" @default.
- W2019923555 abstract "The RV144 phase III clinical trial with the combination of the poxvirus vector ALVAC and the HIV gp120 protein has taught us that a vaccine against HIV/AIDS is possible but further improvements are still needed. Although the HIV protective effect of RV144 was modest (31.2%), these encouraging results reinforce the use of poxvirus vectors as HIV/AIDS vaccine candidates. In this review we focus on the prophylactic clinical studies thus far performed with the more widely studied poxvirus vectors, ALVAC, MVA, NYVAC and fowlpox expressing HIV antigens. We describe the characteristics of each vector administered either alone or in combination with other vectors, with emphasis on the immune parameters evaluated in healthy volunteers, percentage of responders and triggering of humoral and T cell responses. Some of these immunogens induced broad, polyfunctional and long-lasting CD4(+) and CD8(+) T cell responses to HIV-1 antigens in most volunteers, with preference for effector memory T cells, and neutralizing antibodies, immune parameters that might be relevant in protection. Finally, we consider improvements in immunogenicity of the poxvirus vectors by the selective deletion of viral immunomodulatory genes and insertion of host range genes in the poxvirus genome. Overall, the poxvirus vectors have proven to be excellent HIV/AIDS vaccine candidates, with distinct behavior among them, and the future implementation will be dictated by their optimized immune profile in clinical trials." @default.
- W2019923555 created "2016-06-24" @default.
- W2019923555 creator A5030229109 @default.
- W2019923555 creator A5030712042 @default.
- W2019923555 creator A5083111072 @default.
- W2019923555 creator A5088143385 @default.
- W2019923555 date "2012-09-16" @default.
- W2019923555 modified "2023-09-23" @default.
- W2019923555 title "Poxvirus vectors as HIV/AIDS vaccines in humans" @default.
- W2019923555 cites W1524785464 @default.
- W2019923555 cites W1964407118 @default.
- W2019923555 cites W1964552840 @default.
- W2019923555 cites W1965687317 @default.
- W2019923555 cites W1967984729 @default.
- W2019923555 cites W1972959065 @default.
- W2019923555 cites W1977786472 @default.
- W2019923555 cites W1981295860 @default.
- W2019923555 cites W1982008309 @default.
- W2019923555 cites W1984329853 @default.
- W2019923555 cites W1985188429 @default.
- W2019923555 cites W1985611744 @default.
- W2019923555 cites W1985777588 @default.
- W2019923555 cites W1986059049 @default.
- W2019923555 cites W1989087827 @default.
- W2019923555 cites W1991253838 @default.
- W2019923555 cites W1994195272 @default.
- W2019923555 cites W1994749859 @default.
- W2019923555 cites W1995300440 @default.
- W2019923555 cites W1996299849 @default.
- W2019923555 cites W1996383787 @default.
- W2019923555 cites W1998420309 @default.
- W2019923555 cites W1999904021 @default.
- W2019923555 cites W2001436607 @default.
- W2019923555 cites W2004911844 @default.
- W2019923555 cites W2007599113 @default.
- W2019923555 cites W2014694744 @default.
- W2019923555 cites W2018768462 @default.
- W2019923555 cites W2020152654 @default.
- W2019923555 cites W2023231792 @default.
- W2019923555 cites W2026153041 @default.
- W2019923555 cites W2026622904 @default.
- W2019923555 cites W2034863440 @default.
- W2019923555 cites W2036728549 @default.
- W2019923555 cites W2040878504 @default.
- W2019923555 cites W2042067278 @default.
- W2019923555 cites W2042741115 @default.
- W2019923555 cites W2046471199 @default.
- W2019923555 cites W2046593999 @default.
- W2019923555 cites W2055180345 @default.
- W2019923555 cites W2056416333 @default.
- W2019923555 cites W2059505299 @default.
- W2019923555 cites W2062282746 @default.
- W2019923555 cites W2066037887 @default.
- W2019923555 cites W2067396763 @default.
- W2019923555 cites W2068607747 @default.
- W2019923555 cites W2070456312 @default.
- W2019923555 cites W2072191236 @default.
- W2019923555 cites W2073008794 @default.
- W2019923555 cites W2075340091 @default.
- W2019923555 cites W2078685026 @default.
- W2019923555 cites W2079084862 @default.
- W2019923555 cites W2083008217 @default.
- W2019923555 cites W2084092471 @default.
- W2019923555 cites W2084808899 @default.
- W2019923555 cites W2089331972 @default.
- W2019923555 cites W2090359320 @default.
- W2019923555 cites W2091288950 @default.
- W2019923555 cites W2092732192 @default.
- W2019923555 cites W2094438164 @default.
- W2019923555 cites W2094535061 @default.
- W2019923555 cites W2094896122 @default.
- W2019923555 cites W2095662784 @default.
- W2019923555 cites W2096904495 @default.
- W2019923555 cites W2097771941 @default.
- W2019923555 cites W2098590425 @default.
- W2019923555 cites W2099067260 @default.
- W2019923555 cites W2100478383 @default.
- W2019923555 cites W2105323221 @default.
- W2019923555 cites W2107419870 @default.
- W2019923555 cites W2107683840 @default.
- W2019923555 cites W2108103663 @default.
- W2019923555 cites W2109364135 @default.
- W2019923555 cites W2116372466 @default.
- W2019923555 cites W2116738479 @default.
- W2019923555 cites W2126666403 @default.
- W2019923555 cites W2133220937 @default.
- W2019923555 cites W2136281747 @default.
- W2019923555 cites W2137766449 @default.
- W2019923555 cites W2138957964 @default.
- W2019923555 cites W2140483605 @default.
- W2019923555 cites W2141813702 @default.
- W2019923555 cites W2143071104 @default.
- W2019923555 cites W2143421242 @default.
- W2019923555 cites W2145044493 @default.
- W2019923555 cites W2146634980 @default.
- W2019923555 cites W2146962869 @default.
- W2019923555 cites W2147664066 @default.
- W2019923555 cites W2147667061 @default.