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- W2019923621 abstract "The major surface glycoprotein (gp63) of Leishmania major incorporated into the immunostimulating complexes (ISCOMs) was used to protect Balbc mice against experimental infection. Two intraperitoneal vaccinations with low doses of gp63 into ISCOMs (gp63-ISCOMs) induced protective immunity in vaccinated mice as indicated by reduced inflammation and suppressed lesions after experimental challenge. An augmented IgG-specific secretion and a specific switching towards the IgG2a isotype was observed in the serum of vaccinated mice. Gp63-ISCOMs primed spleen cells restimulated in vitro with soluble Leishmania antigen (SLA) or live parasites displayed strong gp63-specific proliferative responses and secreted high levels of interleukin-2, interferon γ and interleukin-10 but not interleukin-4. No delayed type hypersensitivity response to either SLA or LV39 was detected. These data indicate that gp63-ISCOms induced a protective immunity in the susceptible Balbc mice against Leishmania challenge, modulating the immune response towards a Th1 rather than Th2 type." @default.
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- W2019923621 date "1998-05-01" @default.
- W2019923621 modified "2023-09-25" @default.
- W2019923621 title "ISCOMs vaccine against experimental leishmaniasis" @default.
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- W2019923621 doi "https://doi.org/10.1016/s0264-410x(97)00308-3" @default.
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