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- W2019923915 abstract "The association of genes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcriptional regulation. We therefore examined the association of components of the nuclear transport machinery including karyopherins, nucleoporins, and the Ran guanine-nucleotide exchange factor (RanGEF) with the Saccharomyces cerevisiae genome. We find that most nucleoporins and karyopherins preferentially associate with a subset of highly transcribed genes and with genes that possess Rap1 binding sites whereas the RanGEF preferentially associates with transcriptionally inactive genes. Consistent with coupling of transcription to the nuclear pore, we show that transcriptional activation of the GAL genes results in their association with nuclear pore proteins, relocation to the nuclear periphery, and loss of RanGEF association. Taken together, these results indicate that the organization of the genome is coupled via transcriptional state to the nuclear transport machinery." @default.
- W2019923915 created "2016-06-24" @default.
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- W2019923915 date "2004-05-01" @default.
- W2019923915 modified "2023-10-10" @default.
- W2019923915 title "Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization" @default.
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- W2019923915 doi "https://doi.org/10.1016/s0092-8674(04)00448-9" @default.
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