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• W2019925143 abstract "With advances in antiretroviral therapy, many HIV + individuals are living longer lives and some are developing end-stage renal and/or hepatic disease requiring transplantation. These patients require concomitant use of immunosuppressants (e.g., cyclosporine [CsA]) and antiretrovirals (e.g., protease inhibitors [PIs]), which exhibit narrow therapeutic windows and are substrates and inhibitors of cytochrome P450 3A enzymes and the cellular transporter P-glycoprotein. In this pilot study, HIV + subjects on either oral nelfinavir (NFV) or indinavir (IND) with nondetectable viral loads and normal renal and hepatic function had 12 hour pharmacokinetic (PK) studies on 3 separate days: PIs alone, PIs + intravenous CsA, and PIs + oral CsA to determine the extent of PK interactions between these medications. PIs and CsA concentrations were measured by LC/MS in plasma and whole blood, respectively. Nine subjects (n = 7 on NFV, n = 2 on IND) completed the study. Only the results of those subjects taking NFV are reported. Oral co-administration of CsA increased NFV Tmax from 2.6 ± 0.9 to 3.2 ± 0.8 h (p<0.05), and AUC0 -∞ from 27.9±15.2 to 43.2±27.1 mg*h/mL (p = 0.06). Intravenous CsA did not appreciably alter oral pharmacokinetics of NFV. Both CsA and NFV PK parameters exhibited a high degree of intersubject variability, underscoring the need for routine therapeutic drug monitoring of both CsA and PIs in HIV + subjects undergoing transplantation." @default.
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• W2019925143 date "2003-01-01" @default.
• W2019925143 modified "2023-10-10" @default.
• W2019925143 title "Pharmacokinetic Interactions between Cyclosporine and Protease Inhibitors in HIV + Subjects" @default.
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• W2019925143 doi "https://doi.org/10.2133/dmpk.18.114" @default.
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