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- W2019925423 abstract "The circadian rhythm in sleep-response of mice to pentobarbital injection was studied at four different doses. Characteristics of the rhythm, determined by least squares cosine fitting, varied significantly among doses. Parallel-line bioassay of log-transformed data permitted expression of the susceptibility rhythm as a variation in relative potency. Concomitant study of circadian-rhythmic and age-related changes in sleep-response to pentobarbital injection indicated significant differences on both time scales, and the absence of interaction. At circadian phases of long and short sleep duration, brain and blood pentobarbital concentrations were determined at intervals after injection, up to and including the time of awakening. The waking concentrations in brain and blood were significantly higher at the circadian phase of short sleep duration, while time-dependent differences in the rate of barbiturate disappearance from these sites could not be demonstrated. The waking brain pentobarbital concentration at a given circadian phase also differed between 4-month and 9-month old mice. Factors possibly responsible for time-dependent changes in susceptibility to barbiturate injection are discussed." @default.
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- W2019925423 title "An evaluation of time-dependent changes in susceptibility of mice to pentobarbital injection" @default.
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- W2019925423 doi "https://doi.org/10.1016/0028-3908(73)90002-6" @default.
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