FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019927715> ?p ?o ?g. }

• W2019927715 endingPage "22" @default.
• W2019927715 startingPage "11" @default.
• W2019927715 abstract "(1) Liver cells from starved rats were incubated with 10 mM l-lactate, 1 mM pyruvate and 0.3 μM glucagon in the presence and absence of the mild respiratory inhibitor 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) at 0.5 mM. (2) The whole cell concentrations of phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate increased about 2-fold, whilst the triose and hexose phosphate concentrations all decreased significantly. Similar results were obtained with 0.15 μM oligomycin and 10 μM atractyloside. (3) These data can be explained by a substantial decrease in the cytosolic free concentration ratio of ATP/ADP acting on the equilibrium of glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase. (4) The increase in cytosolic phosphoenolpyruvate concentration can account for the observed increase in pyruvate kinase flux that occurs under these conditions (Pryor et al. (1987) Biochem. J. 247, 449–457). (5) An inhibition of pyruvate carboxylase was also implied by a decrease in calculated tissue oxaloacetate concentrations, confirming a role for both enzymes in the inhibition of gluconeogenesis. (6) Whole cell concentrations of effectors of pyruvate carboxylase activity were measured; only the ATP/ADP ratio decreased significantly. (7) Subcellular fractionation studies showed a good correlation between the measured mitochondrial ATP/ADP ratio and rates of gluconeogenesis both in the presence and absence of oleate. (8) A similar correlation could be observed between rates of pyruvate carboxylation and the measured matrix ATP/ADP ratio in isolated liver mitochondria from starved rats. (9) Data are also presented suggesting an additional effect of DCMU on the rate pyruvate carboxylation in situ under some circumstances, mediated by decreases in mitochondrial acetyl-CoA and cytosolic pyruvate concentrations. (10) It is noted that the effects of phenylethylbiguanide (phenformin) on the rate of gluconeogenesis and metabolite profiles in the perfused liver (Cooke et al. (1973) J. Biol. Chem. 248, 5272–5277) are similar to those caused by DCMU, supporting a mitochondrial locus of action for this hypoglycaemic agent." @default.
• W2019927715 created "2016-06-24" @default.
• W2019927715 creator A5015900831 @default.
• W2019927715 creator A5073450017 @default.
• W2019927715 date "1993-04-01" @default.
• W2019927715 modified "2023-10-17" @default.
• W2019927715 title "The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis" @default.
• W2019927715 cites W1237786724 @default.
• W2019927715 cites W1504140615 @default.
• W2019927715 cites W1504336672 @default.
• W2019927715 cites W1506043065 @default.
• W2019927715 cites W1548454840 @default.
• W2019927715 cites W1567345519 @default.
• W2019927715 cites W1577729501 @default.
• W2019927715 cites W1582348132 @default.
• W2019927715 cites W1592085944 @default.
• W2019927715 cites W1679107190 @default.
• W2019927715 cites W1747247635 @default.
• W2019927715 cites W17913752 @default.
• W2019927715 cites W1847382717 @default.
• W2019927715 cites W1853709930 @default.
• W2019927715 cites W193452758 @default.
• W2019927715 cites W1935060748 @default.
• W2019927715 cites W1944498153 @default.
• W2019927715 cites W1971557450 @default.
• W2019927715 cites W1974599587 @default.
• W2019927715 cites W1984770312 @default.
• W2019927715 cites W1987259703 @default.
• W2019927715 cites W1993394330 @default.
• W2019927715 cites W1993462331 @default.
• W2019927715 cites W1998413052 @default.
• W2019927715 cites W2004148053 @default.
• W2019927715 cites W2008449498 @default.
• W2019927715 cites W2011788015 @default.
• W2019927715 cites W2035366073 @default.
• W2019927715 cites W2041755090 @default.
• W2019927715 cites W2045632740 @default.
• W2019927715 cites W2066217484 @default.
• W2019927715 cites W2074570665 @default.
• W2019927715 cites W2079189686 @default.
• W2019927715 cites W2088065710 @default.
• W2019927715 cites W2125277385 @default.
• W2019927715 cites W2128972557 @default.
• W2019927715 cites W2236202509 @default.
• W2019927715 cites W2287382915 @default.
• W2019927715 cites W2336508204 @default.
• W2019927715 cites W2344368547 @default.
• W2019927715 cites W2400962914 @default.
• W2019927715 cites W2420006548 @default.
• W2019927715 cites W2432195370 @default.
• W2019927715 cites W245635694 @default.
• W2019927715 cites W276326461 @default.
• W2019927715 cites W31836502 @default.
• W2019927715 cites W319389768 @default.
• W2019927715 cites W3215218047 @default.
• W2019927715 cites W41657441 @default.
• W2019927715 cites W52539439 @default.
• W2019927715 cites W5661993 @default.
• W2019927715 cites W73017334 @default.
• W2019927715 cites W824290180 @default.
• W2019927715 doi "https://doi.org/10.1016/0005-2728(93)90079-u" @default.
• W2019927715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8457580" @default.
• W2019927715 hasPublicationYear "1993" @default.
• W2019927715 type Work @default.
• W2019927715 sameAs 2019927715 @default.
• W2019927715 citedByCount "36" @default.
• W2019927715 countsByYear W20199277152013 @default.
• W2019927715 countsByYear W20199277152014 @default.
• W2019927715 countsByYear W20199277152015 @default.
• W2019927715 countsByYear W20199277152016 @default.
• W2019927715 countsByYear W20199277152017 @default.
• W2019927715 countsByYear W20199277152018 @default.
• W2019927715 countsByYear W20199277152019 @default.
• W2019927715 countsByYear W20199277152020 @default.
• W2019927715 countsByYear W20199277152021 @default.
• W2019927715 countsByYear W20199277152023 @default.
• W2019927715 crossrefType "journal-article" @default.
• W2019927715 hasAuthorship W2019927715A5015900831 @default.
• W2019927715 hasAuthorship W2019927715A5073450017 @default.
• W2019927715 hasConcept C101972281 @default.
• W2019927715 hasConcept C140137476 @default.
• W2019927715 hasConcept C143937172 @default.
• W2019927715 hasConcept C181199279 @default.
• W2019927715 hasConcept C185592680 @default.
• W2019927715 hasConcept C20251656 @default.
• W2019927715 hasConcept C20904676 @default.
• W2019927715 hasConcept C23265538 @default.
• W2019927715 hasConcept C2776317432 @default.
• W2019927715 hasConcept C2779134199 @default.
• W2019927715 hasConcept C2780854706 @default.
• W2019927715 hasConcept C2781272698 @default.
• W2019927715 hasConcept C55493867 @default.
• W2019927715 hasConcept C86803240 @default.
• W2019927715 hasConcept C9506865 @default.
• W2019927715 hasConcept C98539663 @default.
• W2019927715 hasConceptScore W2019927715C101972281 @default.
• W2019927715 hasConceptScore W2019927715C140137476 @default.
• W2019927715 hasConceptScore W2019927715C143937172 @default.

• next