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- W2019927913 abstract "Anesthetic development has been a largely empirical process. Recently, we described a GABAergic mimetic model system for anesthetic binding, based on apoferritin and an environment-sensitive fluorescent probe. Here, a competition assay based on 1-aminoanthracene and apoferritin has been taken to a high throughput screening level, and validated using the LOPAC1280 library of drug-like compounds. A raw hit rate of ∼15% was reduced through the use of computational filters to yield an overall hit rate of ∼1%. These hits were validated using isothermal titration calorimetry. The success of this initial screen and computational triage provides feasibility to undergo a large scale campaign to discover novel general anesthetics." @default.
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- W2019927913 date "2009-09-24" @default.
- W2019927913 modified "2023-10-16" @default.
- W2019927913 title "A High-Throughput Approach for Identification of Novel General Anesthetics" @default.
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- W2019927913 doi "https://doi.org/10.1371/journal.pone.0007150" @default.
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