FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019928999> ?p ?o ?g. }

• W2019928999 endingPage "652" @default.
• W2019928999 startingPage "646" @default.
• W2019928999 abstract "Objective To analyse the influence of mitochondrial DNA haplogroups, as well as the radiographic grade, on serum levels of proteolytic enzymes in patients with osteoarthritis (OA). Methods Serum levels of metalloproteinase-1 (MMP-1), MMP-3, MMP-13, myeloperoxidase and cathepsin K were analysed in 73 patients with OA and 77 healthy controls carrying the haplogroups J, U and H, by ELISA. Knee and hip radiographs were classified according to Kellgren and Lawrence (K/L) scoring from grade 0 to grade IV. Non-parametric and multiple regression analyses were performed to test the effects of clinical variables, including gender, age, smoking status, diagnosis, haplogroups and radiological K/L grade on serum levels of these enzymes. Results A significant influence of the haplogroups on the serum levels of MMP-3 and MMP-13 was detected (p=0.027 and p=0.035, respectively). Patients with OA with haplogroup H showed higher serum levels of MMP-3 than healthy controls. Serum levels of MMP-13 were significantly higher in patients with OA (p<0.001), and carriers of the haplogroup J showed lower levels than H carriers. Besides, levels of MMP-13 were proportionally higher in radiological groups B (K/L grade II and III) and C (K/L grade IV) than in group A (K/L grade 0 and I) (p=0.005). Conclusions This study shows that haplogroups have a significant influence on serum levels of MMP-3 and MMP-13. The influence of the haplogroups on serum levels of MMP-3 is clearly dependent on the diagnosis, whereas the influence of the haplogroups on serum levels of MMP-13 is independent of diagnosis." @default.
• W2019928999 created "2016-06-24" @default.
• W2019928999 creator A5007718516 @default.
• W2019928999 creator A5012454701 @default.
• W2019928999 creator A5015794417 @default.
• W2019928999 creator A5019232047 @default.
• W2019928999 creator A5019811024 @default.
• W2019928999 creator A5031012647 @default.
• W2019928999 creator A5083304899 @default.
• W2019928999 creator A5087305197 @default.
• W2019928999 date "2010-12-21" @default.
• W2019928999 modified "2023-10-13" @default.
• W2019928999 title "Mitochondrial DNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis" @default.
• W2019928999 cites W1482123720 @default.
• W2019928999 cites W1738163001 @default.
• W2019928999 cites W1967057044 @default.
• W2019928999 cites W1979972616 @default.
• W2019928999 cites W1985073265 @default.
• W2019928999 cites W1987469947 @default.
• W2019928999 cites W1990630360 @default.
• W2019928999 cites W1996923449 @default.
• W2019928999 cites W2001952131 @default.
• W2019928999 cites W2005758857 @default.
• W2019928999 cites W2014732422 @default.
• W2019928999 cites W2021614659 @default.
• W2019928999 cites W2032097381 @default.
• W2019928999 cites W2039158596 @default.
• W2019928999 cites W2058147305 @default.
• W2019928999 cites W2062522737 @default.
• W2019928999 cites W2066161297 @default.
• W2019928999 cites W2075978331 @default.
• W2019928999 cites W2086096794 @default.
• W2019928999 cites W2086866915 @default.
• W2019928999 cites W2088649670 @default.
• W2019928999 cites W2095915630 @default.
• W2019928999 cites W2100292041 @default.
• W2019928999 cites W2102357280 @default.
• W2019928999 cites W2103939468 @default.
• W2019928999 cites W2105754268 @default.
• W2019928999 cites W2106162990 @default.
• W2019928999 cites W2115824889 @default.
• W2019928999 cites W2125310185 @default.
• W2019928999 cites W2126399839 @default.
• W2019928999 cites W2128727242 @default.
• W2019928999 cites W2138960046 @default.
• W2019928999 cites W2140141322 @default.
• W2019928999 cites W2142887926 @default.
• W2019928999 cites W2145999869 @default.
• W2019928999 cites W2162582160 @default.
• W2019928999 cites W2342129036 @default.
• W2019928999 cites W2498491881 @default.
• W2019928999 cites W2502727756 @default.
• W2019928999 cites W3158297204 @default.
• W2019928999 doi "https://doi.org/10.1136/ard.2010.133637" @default.
• W2019928999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21177294" @default.
• W2019928999 hasPublicationYear "2010" @default.
• W2019928999 type Work @default.
• W2019928999 sameAs 2019928999 @default.
• W2019928999 citedByCount "32" @default.
• W2019928999 countsByYear W20199289992012 @default.
• W2019928999 countsByYear W20199289992013 @default.
• W2019928999 countsByYear W20199289992014 @default.
• W2019928999 countsByYear W20199289992015 @default.
• W2019928999 countsByYear W20199289992016 @default.
• W2019928999 countsByYear W20199289992017 @default.
• W2019928999 countsByYear W20199289992018 @default.
• W2019928999 countsByYear W20199289992019 @default.
• W2019928999 countsByYear W20199289992020 @default.
• W2019928999 countsByYear W20199289992021 @default.
• W2019928999 countsByYear W20199289992022 @default.
• W2019928999 countsByYear W20199289992023 @default.
• W2019928999 crossrefType "journal-article" @default.
• W2019928999 hasAuthorship W2019928999A5007718516 @default.
• W2019928999 hasAuthorship W2019928999A5012454701 @default.
• W2019928999 hasAuthorship W2019928999A5015794417 @default.
• W2019928999 hasAuthorship W2019928999A5019232047 @default.
• W2019928999 hasAuthorship W2019928999A5019811024 @default.
• W2019928999 hasAuthorship W2019928999A5031012647 @default.
• W2019928999 hasAuthorship W2019928999A5083304899 @default.
• W2019928999 hasAuthorship W2019928999A5087305197 @default.
• W2019928999 hasConcept C104317684 @default.
• W2019928999 hasConcept C126322002 @default.
• W2019928999 hasConcept C135763542 @default.
• W2019928999 hasConcept C142724271 @default.
• W2019928999 hasConcept C181199279 @default.
• W2019928999 hasConcept C197754878 @default.
• W2019928999 hasConcept C201526758 @default.
• W2019928999 hasConcept C204787440 @default.
• W2019928999 hasConcept C2776164576 @default.
• W2019928999 hasConcept C3019223276 @default.
• W2019928999 hasConcept C55493867 @default.
• W2019928999 hasConcept C71924100 @default.
• W2019928999 hasConcept C78450430 @default.
• W2019928999 hasConcept C86803240 @default.
• W2019928999 hasConcept C90924648 @default.
• W2019928999 hasConceptScore W2019928999C104317684 @default.
• W2019928999 hasConceptScore W2019928999C126322002 @default.
• W2019928999 hasConceptScore W2019928999C135763542 @default.

• next