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• W2019929119 abstract "Vascular endothelial growth factor (VEGF) is the major molecule governing angiogenesis, defined as the growth of blood vessels from vascular structure. There is abundant evidence that nitric oxide (NO) is an effector molecule mediating the activity of VEGF. By binding to its receptors, VEGF initiates the signaling cascades leading to NO production and angiogenic activation of endothelial cells. Recent data show that NO induces VEGF synthesis in numerous cell types, including vascular smooth muscle cells, macrophages, keratinocytes, and tumor cells. NO enhances VEGF production by augmenting its expression through activation of Akt kinase, followed by induction of several transcription factors, of which stabilization of hypoxia-inducible factor (HIF-1) is the critical step. With respect to its effect on VEGF expression, NO mimics hypoxia, the classical activator of HIF-1 and VEGF synthesis. The effect of NO on VEGF production is also mediated by heme oxygenase, an enzyme generating carbon monoxide, which appears to stimulate VEGF release. In this review, we attempt to elucidate the molecular mechanisms underlying the effects of NO on VEGF synthesis. We also discuss some discrepant data and suggest explanations for various aspects of the NO-VEGF relationship." @default.
• W2019929119 created "2016-06-24" @default.
• W2019929119 creator A5075717051 @default.
• W2019929119 creator A5082864592 @default.
• W2019929119 date "2003-02-01" @default.
• W2019929119 modified "2023-10-18" @default.
• W2019929119 title "Regulation of Vascular Endothelial Growth Factor Synthesis by Nitric Oxide: Facts and Controversies" @default.
• W2019929119 cites W1488835155 @default.
• W2019929119 cites W1537712767 @default.
• W2019929119 cites W1749022239 @default.
• W2019929119 cites W1864236397 @default.
• W2019929119 cites W191429942 @default.
• W2019929119 cites W1934754959 @default.
• W2019929119 cites W1964037605 @default.
• W2019929119 cites W1967203013 @default.
• W2019929119 cites W1970242273 @default.
• W2019929119 cites W1973092951 @default.
• W2019929119 cites W1973898220 @default.
• W2019929119 cites W1975545468 @default.
• W2019929119 cites W1976693476 @default.
• W2019929119 cites W1980544596 @default.
• W2019929119 cites W1984973903 @default.
• W2019929119 cites W1985112972 @default.
• W2019929119 cites W1988677180 @default.
• W2019929119 cites W1989704413 @default.
• W2019929119 cites W1990187729 @default.
• W2019929119 cites W1993142911 @default.
• W2019929119 cites W2000624133 @default.
• W2019929119 cites W2003664528 @default.
• W2019929119 cites W2003820681 @default.
• W2019929119 cites W2006358233 @default.
• W2019929119 cites W2006861037 @default.
• W2019929119 cites W2010057452 @default.
• W2019929119 cites W2012677679 @default.
• W2019929119 cites W2015058903 @default.
• W2019929119 cites W2018474491 @default.
• W2019929119 cites W2020242649 @default.
• W2019929119 cites W2023243666 @default.
• W2019929119 cites W2023633834 @default.
• W2019929119 cites W2024875928 @default.
• W2019929119 cites W2026783909 @default.
• W2019929119 cites W2027817420 @default.
• W2019929119 cites W2035805891 @default.
• W2019929119 cites W2040031153 @default.
• W2019929119 cites W2045727091 @default.
• W2019929119 cites W2046905314 @default.
• W2019929119 cites W2048741717 @default.
• W2019929119 cites W2049299765 @default.
• W2019929119 cites W2050754416 @default.
• W2019929119 cites W2058400833 @default.
• W2019929119 cites W2060254175 @default.
• W2019929119 cites W2062093468 @default.
• W2019929119 cites W2065062610 @default.
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• W2019929119 cites W2082424920 @default.
• W2019929119 cites W2090241785 @default.
• W2019929119 cites W2091499945 @default.
• W2019929119 cites W2091581243 @default.
• W2019929119 cites W2094267083 @default.
• W2019929119 cites W2098364808 @default.
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• W2019929119 cites W2125690417 @default.
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• W2019929119 cites W2133667940 @default.
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• W2019929119 cites W2141046053 @default.
• W2019929119 cites W2141537184 @default.
• W2019929119 cites W2141558413 @default.
• W2019929119 cites W2144625075 @default.
• W2019929119 cites W2145530136 @default.
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• W2019929119 cites W2153805504 @default.
• W2019929119 cites W2159600810 @default.
• W2019929119 cites W2163069245 @default.
• W2019929119 cites W2163981817 @default.
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• W2019929119 cites W2199292288 @default.
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• W2019929119 doi "https://doi.org/10.1089/152308603321223612" @default.
• W2019929119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12626124" @default.
• W2019929119 hasPublicationYear "2003" @default.
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