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- W2019929496 abstract "Genome-wide scans in bipolar disorder and a meta analysis on published data have provided evidence for linkage to chromosome 13q, although the reported peaks from various studies have not converged in a narrow region. Recently, single nucleotide polymorphisms (SNPs) at the G72/G30 locus have been shown to be associated with bipolar disorder suggesting its potential role in increasing disease risk. The proposed linkage region on 13q extends over a wide span, and could provide a clue to the existence of other susceptibility variants. In the present study, SNPs in the LOC93081-KDELC1-BIVM, a region proximal to G72, were interrogated in two bipolar family series. KDELC1 has a predicted filamin domain and BIVM contains an immunoglobulin-like motif. The small pedigree series yielded a nominally significant global P-value due to under-transmission of a rare haplotype but this finding was not supported by results from the larger series and in the case-control study that compared 278 cases and 277 controls." @default.
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- W2019929496 date "2005-01-01" @default.
- W2019929496 modified "2023-09-24" @default.
- W2019929496 title "Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder" @default.
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- W2019929496 doi "https://doi.org/10.1002/ajmg.b.30121" @default.
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