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• W2019929518 abstract "BackgroundIsolated Ara h 8 sensitization is suggested to be associated with no or mild symptoms among peanut-sensitized subjects.ObjectiveWe sought to investigate the occurrence of systemic reactions in children with isolated sensitization to Ara h 8.MethodsParticipants were 144 children sensitized to Ara h 8 (≥0.35 kUA/L) but not to Ara h 1, Ara h 2, or Ara h 3 (<0.35 kUA/L). An open oral challenge with peanut was performed in those subjects who did not consume peanut regularly, and an extended IgE reactivity profile was obtained. If the child had a documented history of systemic reactions up to grade I anaphylaxis, double-blind, placebo-controlled food challenges were performed.ResultsOne hundred twenty-nine (89.5%) children were either peanut consumers or did not react to peanut challenge. Another 14 (9.7%) children experienced oral cavity symptoms at the first 2 but not subsequent challenge doses. At the time of the double-blind, placebo-controlled food challenge, 1 boy with a previous mild systemic reaction to peanut experienced lip swelling, stomach cramping, and objective tiredness. Reanalysis of IgE levels showed an increase in peanut IgE levels from 1.5 to 8.8 kUA/L, but IgE levels to Ara h 8 remained stable and IgE levels to Ara h 1, Ara h 2, and Ara h 3 were all still less than 0.35 kUA/L. The IgE level to Ara h 6 was 0.45 kUA/L.ConclusionIsolated Ara h 8 sensitization indicates tolerance to peanuts in almost all cases. However, sensitization against thus far unidentified determinants in peanut might cause symptoms in rare cases. Isolated Ara h 8 sensitization is suggested to be associated with no or mild symptoms among peanut-sensitized subjects. We sought to investigate the occurrence of systemic reactions in children with isolated sensitization to Ara h 8. Participants were 144 children sensitized to Ara h 8 (≥0.35 kUA/L) but not to Ara h 1, Ara h 2, or Ara h 3 (<0.35 kUA/L). An open oral challenge with peanut was performed in those subjects who did not consume peanut regularly, and an extended IgE reactivity profile was obtained. If the child had a documented history of systemic reactions up to grade I anaphylaxis, double-blind, placebo-controlled food challenges were performed. One hundred twenty-nine (89.5%) children were either peanut consumers or did not react to peanut challenge. Another 14 (9.7%) children experienced oral cavity symptoms at the first 2 but not subsequent challenge doses. At the time of the double-blind, placebo-controlled food challenge, 1 boy with a previous mild systemic reaction to peanut experienced lip swelling, stomach cramping, and objective tiredness. Reanalysis of IgE levels showed an increase in peanut IgE levels from 1.5 to 8.8 kUA/L, but IgE levels to Ara h 8 remained stable and IgE levels to Ara h 1, Ara h 2, and Ara h 3 were all still less than 0.35 kUA/L. The IgE level to Ara h 6 was 0.45 kUA/L. Isolated Ara h 8 sensitization indicates tolerance to peanuts in almost all cases. However, sensitization against thus far unidentified determinants in peanut might cause symptoms in rare cases." @default.
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• W2019929518 date "2012-08-01" @default.
• W2019929518 modified "2023-10-17" @default.
• W2019929518 title "Peanut component Ara h 8 sensitization and tolerance to peanut" @default.
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• W2019929518 doi "https://doi.org/10.1016/j.jaci.2012.05.019" @default.
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