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• W2019930774 abstract "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in cancer cells and is verified to be effective in various cancers. However, a variety of cancer cells are found to be resistant to TRAIL and the mechanisms are largely unknown. Moreover, multidrug resistance to traditional chemotherapeutic agents still remains a tough problem in clinical practice. Fortunately, our previous work proved the ability of PH II-7 in overcoming MDR phenotype through reactive oxygen species production in K562 and its MDR counterpart K562/A02 cells. Additionally, we further explored its potential in augmenting TRAIL induced apoptosis in cancer cells with various tissue origins. Our results showed PH II-7 up-regulated DR4/DR5 expression and augment TRAIL cytotoxicity through reactive oxygen species production, which provide a solid foundation for TRAIL in combination with PH II-7 in future clinical application." @default.
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• W2019930774 date "2015-01-01" @default.
• W2019930774 modified "2023-10-18" @default.
• W2019930774 title "Reactive oxygen species contribute to TRAIL receptors upregulation; the mechanism for PH II-7 augmenting TRAIL induced apoptosis in leukemia cells" @default.
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• W2019930774 doi "https://doi.org/10.1016/j.ejphar.2014.10.028" @default.
• W2019930774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446561" @default.
• W2019930774 hasPublicationYear "2015" @default.
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