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- W2019931350 abstract "Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth factor receptors. A targeted inactivation of Jak2 was performed. Jak2−/− embryos are anemic and die around day 12.5 postcoitum. Primitive erythrocytes are found, but definitive erythropoiesis is absent. Compared to erythropoietin receptor–deficient mice, the phenotype of Jak2 deficiency is more severe. Fetal liver BFU-E and CFU-E colonies are completely absent. However, multilineage hematopoietic stem cells (CD34low, c-kitpos) can be found, and B lymphopoiesis appears intact. In contrast to IFNα stimulation, Jak2−/− cells do not respond to IFNγ. Jak2−/− embryonic stem cells are competent for LIF signaling. The data provided demonstrate that Jak2 has pivotal functions for signal transduction of a set of cytokine receptors required in definitive erythropoiesis." @default.
- W2019931350 created "2016-06-24" @default.
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- W2019931350 creator A5044756037 @default.
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- W2019931350 date "1998-05-01" @default.
- W2019931350 modified "2023-10-11" @default.
- W2019931350 title "Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis" @default.
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- W2019931350 doi "https://doi.org/10.1016/s0092-8674(00)81168-x" @default.
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