Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019932047> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2019932047 endingPage "565" @default.
- W2019932047 startingPage "561" @default.
- W2019932047 abstract "Peripheral lipopolysaccharide (LPS) or proinflammatory cytokines produce alterations in learning, memory, and other behaviors. Additionally, research has demonstrated that factors such as dose, route of administration, species, strain, gender, and age are important modulatory factors in the effects of endotoxin exposure. Previous research from our laboratory and others indicate that LPS-induced behavioral deficits are greater in older subjects. The current study examined avoidance learning in a negatively reinforced operant procedure (i.e., two-way active avoidance conditioning) following single or repeated intraperitoneal LPS injections in 2- and 12-month-old male C57BL/6J mice. LPS-treated subjects show impaired acquisition of the task regardless of the age of the subject, as these animals performed significantly fewer avoidance responses than controls. However, the effects of LPS administration were more pronounced in the 12-month-old animals, particularly for the subjects given repeated LPS injections. These results support the hypothesis that endotoxin exposure is capable of altering performance in this task in a way that may reflect deficits in learning, and provide evidence that increased age may exacerbate these deleterious behavioral effects." @default.
- W2019932047 created "2016-06-24" @default.
- W2019932047 creator A5026676758 @default.
- W2019932047 creator A5055159541 @default.
- W2019932047 creator A5057830583 @default.
- W2019932047 creator A5089466530 @default.
- W2019932047 date "2007-08-01" @default.
- W2019932047 modified "2023-09-25" @default.
- W2019932047 title "Age increases vulnerability to bacterial endotoxin-induced behavioral decrements" @default.
- W2019932047 cites W1945510071 @default.
- W2019932047 cites W1963918819 @default.
- W2019932047 cites W2011672325 @default.
- W2019932047 cites W2022209797 @default.
- W2019932047 cites W2034337512 @default.
- W2019932047 cites W2039296833 @default.
- W2019932047 cites W2039390013 @default.
- W2019932047 cites W2043464691 @default.
- W2019932047 cites W2052884971 @default.
- W2019932047 cites W2053744705 @default.
- W2019932047 cites W2061931936 @default.
- W2019932047 cites W2062790940 @default.
- W2019932047 cites W2067790206 @default.
- W2019932047 cites W2071129128 @default.
- W2019932047 cites W2078141958 @default.
- W2019932047 cites W2089406620 @default.
- W2019932047 cites W2128737275 @default.
- W2019932047 cites W2154653323 @default.
- W2019932047 cites W4292340975 @default.
- W2019932047 doi "https://doi.org/10.1016/j.physbeh.2007.03.032" @default.
- W2019932047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17499821" @default.
- W2019932047 hasPublicationYear "2007" @default.
- W2019932047 type Work @default.
- W2019932047 sameAs 2019932047 @default.
- W2019932047 citedByCount "32" @default.
- W2019932047 countsByYear W20199320472012 @default.
- W2019932047 countsByYear W20199320472013 @default.
- W2019932047 countsByYear W20199320472015 @default.
- W2019932047 countsByYear W20199320472017 @default.
- W2019932047 countsByYear W20199320472018 @default.
- W2019932047 countsByYear W20199320472019 @default.
- W2019932047 countsByYear W20199320472020 @default.
- W2019932047 countsByYear W20199320472021 @default.
- W2019932047 crossrefType "journal-article" @default.
- W2019932047 hasAuthorship W2019932047A5026676758 @default.
- W2019932047 hasAuthorship W2019932047A5055159541 @default.
- W2019932047 hasAuthorship W2019932047A5057830583 @default.
- W2019932047 hasAuthorship W2019932047A5089466530 @default.
- W2019932047 hasConcept C105795698 @default.
- W2019932047 hasConcept C126322002 @default.
- W2019932047 hasConcept C138496976 @default.
- W2019932047 hasConcept C138906646 @default.
- W2019932047 hasConcept C146926590 @default.
- W2019932047 hasConcept C15744967 @default.
- W2019932047 hasConcept C164027704 @default.
- W2019932047 hasConcept C169760540 @default.
- W2019932047 hasConcept C2776914184 @default.
- W2019932047 hasConcept C2778754761 @default.
- W2019932047 hasConcept C2993535909 @default.
- W2019932047 hasConcept C33923547 @default.
- W2019932047 hasConcept C42407357 @default.
- W2019932047 hasConcept C45262634 @default.
- W2019932047 hasConcept C71924100 @default.
- W2019932047 hasConceptScore W2019932047C105795698 @default.
- W2019932047 hasConceptScore W2019932047C126322002 @default.
- W2019932047 hasConceptScore W2019932047C138496976 @default.
- W2019932047 hasConceptScore W2019932047C138906646 @default.
- W2019932047 hasConceptScore W2019932047C146926590 @default.
- W2019932047 hasConceptScore W2019932047C15744967 @default.
- W2019932047 hasConceptScore W2019932047C164027704 @default.
- W2019932047 hasConceptScore W2019932047C169760540 @default.
- W2019932047 hasConceptScore W2019932047C2776914184 @default.
- W2019932047 hasConceptScore W2019932047C2778754761 @default.
- W2019932047 hasConceptScore W2019932047C2993535909 @default.
- W2019932047 hasConceptScore W2019932047C33923547 @default.
- W2019932047 hasConceptScore W2019932047C42407357 @default.
- W2019932047 hasConceptScore W2019932047C45262634 @default.
- W2019932047 hasConceptScore W2019932047C71924100 @default.
- W2019932047 hasIssue "5" @default.
- W2019932047 hasLocation W20199320471 @default.
- W2019932047 hasLocation W20199320472 @default.
- W2019932047 hasOpenAccess W2019932047 @default.
- W2019932047 hasPrimaryLocation W20199320471 @default.
- W2019932047 hasRelatedWork W1974983198 @default.
- W2019932047 hasRelatedWork W1997011797 @default.
- W2019932047 hasRelatedWork W2008202586 @default.
- W2019932047 hasRelatedWork W2011302661 @default.
- W2019932047 hasRelatedWork W2050037580 @default.
- W2019932047 hasRelatedWork W2073162900 @default.
- W2019932047 hasRelatedWork W2078141958 @default.
- W2019932047 hasRelatedWork W2094304727 @default.
- W2019932047 hasRelatedWork W2192590440 @default.
- W2019932047 hasRelatedWork W2477300433 @default.
- W2019932047 hasVolume "91" @default.
- W2019932047 isParatext "false" @default.
- W2019932047 isRetracted "false" @default.
- W2019932047 magId "2019932047" @default.
- W2019932047 workType "article" @default.