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- W2019933953 abstract "Introduction: Cell cycle regulators determine behaviorproliferation and apoptosisof malignancy: p53 regulates cell cycle and its mutated nonfunctional form may be demonstrated; War 1 is a negative regulator of cell cycle; bcl-2 blocks apoptosis; MIBI stains Ki-67 protein, which is expressed in actively proliferating cells. First generation prognostic factors (age, gender, site, stage, type, grade, resection line disease) have been extensively evaluated in gastric carcinoma. Methods: We reviewed the clinical parameters and pathological materials of 103 patients who had undergone staging and curative (T1-3,N0-1,M0) or palliative (T1-4,N1-2, M0-1) resection of gastric carcinoma between 19881991, and who had been completely followed up for more than 5 years. Archival blocks were reproeessed and immunocytochemical detection obtained for p53 (Dako A/S, Copenghagen), Waf 1 (Novo-Castro, Newcastle on Tyne), MIB1 (Calibiochem, CA, and bcl-2 (Dako A/S, Copenhagen), and the biomarker expression assessed. Statistical methods used were univariate and Cox regression analysis. Results: The overall 5 year survival rate was 37%. Univariate analysis showed no significant difference when expression / not of p53, WAF1, MIB1, and bcl-2 were compared. The first generation factors had significant prognostic impact: T stage (p=0.01), N stage (p=0.0003), and M stage (p=0.018); no significant difference was found with age ( 60 yrs), gender, type (intestinal/diffuse), grade (well, moderately-, poorly differentiated), or site (proximal/distal). Cox regression analysis, however, found the following sequential ratios of risk (RR): N stage (2.03), T stage (1.75), M stage (1.72), gender (1.21), p53 (1.16), MIB1 (1.13). All other factors had a RR<I. There was no correlation between p53, WAF1, MIB1, and bcl-2 when these were independently correlated with the variables of type, grade and stage. Conclusions: The first generation factor of stage was the most powerful predictor of prognosis; the biological markers p53 and MIB1 (but not bcl-2 and Waf 1), correlated weakly with prognosis. These biological markers did not correlate with type, grade, and stage." @default.
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- W2019933953 date "1998-04-01" @default.
- W2019933953 modified "2023-09-27" @default.
- W2019933953 title "p53, WAF1, MIB1, bcl-2 as prognostic determinants in comparison to first generation prognostic factors in gastric carcinoma" @default.
- W2019933953 doi "https://doi.org/10.1016/s0016-5085(98)82726-1" @default.
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