FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019933976> ?p ?o ?g. }

• W2019933976 endingPage "90" @default.
• W2019933976 startingPage "83" @default.
• W2019933976 abstract "Adrenomedullin (AM) has been demonstrated to be involved in the development of opioid tolerance. The present study further investigated the role of AM in the maintenance of morphine tolerance, morphine-associated hyperalgesia and its cellular mechanisms. Intrathecal (i.t.) injection of morphine for 6 days induced a decline of its analgesic effect and hyperalgesia. Acute administration of the AM receptor antagonist AM(22-52) resumed the potency of morphine in a dose-dependent manner (12, 35.8 and 71.5 μg, i.t.). The AM(22-52) treatment also suppressed morphine tolerance-associated hyperalgesia. Furthermore, i.t. administration of AM(22-52) at a dose of 35.8 μg reversed the morphine induced-enhancement of nNOS (neuronal nitric oxide synthase) and CGRP immunoreactivity in the spinal dorsal horn and/or dorsal root ganglia (DRG). Interestingly, chronic administration of morphine reduced the expression of the endogenous opioid peptide bovine adrenal medulla 22 (BAM22) in small- and medium-sized neurons in DRG and this reduction was partially reversed by the administration of AM(22-52) (35.8 μg). These results suggest that the activation of AM receptors was involved in the maintenance of morphine tolerance mediating by not only upregulation of the pronociceptive mediators, nNOS and CGRP but also the down-regulation of pain-inhibiting molecule BAM22. Our data support the hypothesis that the level of both pronociceptive mediators and endogenous pain-inhibiting molecules has an impact on the potency of morphine analgesia. Targeting AM receptors is a promising approach to maintain the potency of morphine analgesia during chronic use of this drug." @default.
• W2019933976 created "2016-06-24" @default.
• W2019933976 creator A5013123610 @default.
• W2019933976 creator A5040308869 @default.
• W2019933976 creator A5045259974 @default.
• W2019933976 creator A5055183128 @default.
• W2019933976 creator A5056246750 @default.
• W2019933976 date "2011-08-01" @default.
• W2019933976 modified "2023-09-23" @default.
• W2019933976 title "Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms" @default.
• W2019933976 cites W1531160152 @default.
• W2019933976 cites W1625856702 @default.
• W2019933976 cites W1968047901 @default.
• W2019933976 cites W1968297421 @default.
• W2019933976 cites W1971992833 @default.
• W2019933976 cites W1973861678 @default.
• W2019933976 cites W1978542151 @default.
• W2019933976 cites W1982465020 @default.
• W2019933976 cites W1982643415 @default.
• W2019933976 cites W1993468298 @default.
• W2019933976 cites W2003013600 @default.
• W2019933976 cites W2013798589 @default.
• W2019933976 cites W2014072624 @default.
• W2019933976 cites W2016119431 @default.
• W2019933976 cites W2016715670 @default.
• W2019933976 cites W2017379748 @default.
• W2019933976 cites W2027128206 @default.
• W2019933976 cites W2031081542 @default.
• W2019933976 cites W2031597991 @default.
• W2019933976 cites W2033400860 @default.
• W2019933976 cites W2040725197 @default.
• W2019933976 cites W2044285853 @default.
• W2019933976 cites W2045147289 @default.
• W2019933976 cites W2051279593 @default.
• W2019933976 cites W2055873275 @default.
• W2019933976 cites W2057898049 @default.
• W2019933976 cites W2059558814 @default.
• W2019933976 cites W2061344772 @default.
• W2019933976 cites W2062714491 @default.
• W2019933976 cites W2069451667 @default.
• W2019933976 cites W2077214024 @default.
• W2019933976 cites W2078304896 @default.
• W2019933976 cites W2081046387 @default.
• W2019933976 cites W2082772875 @default.
• W2019933976 cites W2090187545 @default.
• W2019933976 cites W2090743005 @default.
• W2019933976 cites W2102780227 @default.
• W2019933976 cites W2123258170 @default.
• W2019933976 cites W2126280099 @default.
• W2019933976 cites W2129889492 @default.
• W2019933976 cites W2130400455 @default.
• W2019933976 cites W2133676685 @default.
• W2019933976 cites W2138667683 @default.
• W2019933976 cites W2154084570 @default.
• W2019933976 cites W2161622672 @default.
• W2019933976 cites W2163114191 @default.
• W2019933976 doi "https://doi.org/10.1016/j.bbr.2011.02.046" @default.
• W2019933976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21382419" @default.
• W2019933976 hasPublicationYear "2011" @default.
• W2019933976 type Work @default.
• W2019933976 sameAs 2019933976 @default.
• W2019933976 citedByCount "19" @default.
• W2019933976 countsByYear W20199339762012 @default.
• W2019933976 countsByYear W20199339762013 @default.
• W2019933976 countsByYear W20199339762014 @default.
• W2019933976 countsByYear W20199339762016 @default.
• W2019933976 countsByYear W20199339762019 @default.
• W2019933976 countsByYear W20199339762020 @default.
• W2019933976 countsByYear W20199339762021 @default.
• W2019933976 countsByYear W20199339762022 @default.
• W2019933976 crossrefType "journal-article" @default.
• W2019933976 hasAuthorship W2019933976A5013123610 @default.
• W2019933976 hasAuthorship W2019933976A5040308869 @default.
• W2019933976 hasAuthorship W2019933976A5045259974 @default.
• W2019933976 hasAuthorship W2019933976A5055183128 @default.
• W2019933976 hasAuthorship W2019933976A5056246750 @default.
• W2019933976 hasConcept C118303440 @default.
• W2019933976 hasConcept C126322002 @default.
• W2019933976 hasConcept C134018914 @default.
• W2019933976 hasConcept C14397066 @default.
• W2019933976 hasConcept C15490471 @default.
• W2019933976 hasConcept C163170386 @default.
• W2019933976 hasConcept C170493617 @default.
• W2019933976 hasConcept C185592680 @default.
• W2019933976 hasConcept C2777152744 @default.
• W2019933976 hasConcept C2777389121 @default.
• W2019933976 hasConcept C2779245659 @default.
• W2019933976 hasConcept C2779985140 @default.
• W2019933976 hasConcept C2781063702 @default.
• W2019933976 hasConcept C71924100 @default.
• W2019933976 hasConcept C98274493 @default.
• W2019933976 hasConceptScore W2019933976C118303440 @default.
• W2019933976 hasConceptScore W2019933976C126322002 @default.
• W2019933976 hasConceptScore W2019933976C134018914 @default.
• W2019933976 hasConceptScore W2019933976C14397066 @default.
• W2019933976 hasConceptScore W2019933976C15490471 @default.
• W2019933976 hasConceptScore W2019933976C163170386 @default.
• W2019933976 hasConceptScore W2019933976C170493617 @default.

• next