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- W2019934240 endingPage "3080" @default.
- W2019934240 startingPage "3080" @default.
- W2019934240 abstract "Associated with the CD1d protein, KRN 7000, a potent synthetic α-galactosylceramide, is known to activate the invariant NKT immune cells. This stimulation then leads to the production of different cytokines modulating a T(H)1/T(H)2 immune response balance involved in protection against several pathologies such as autoimmune diseases and cancers. Various efforts have been made toward the synthesis of simple and more functionalized analogues in order to selectively induce T(H)1 or T(H)2-type cytokine production. Since the discovery of KRN 7000, structure-activity relationships, crystallographic and modelling studies have pointed to the potential of several GalCer analogues in term of selective bioactivity, and have highlighted interesting elements in order to better understand the recognition and activation mechanisms of immune iNKT cells. By presenting an up-to-date library of analogues, collecting recent breakthroughs done in crystallography and molecular modelling, and relating them to the available biological results, we hope that this review will highlight and help the scientific community in their KRN research." @default.
- W2019934240 created "2016-06-24" @default.
- W2019934240 creator A5000596916 @default.
- W2019934240 creator A5004006480 @default.
- W2019934240 creator A5016118429 @default.
- W2019934240 creator A5016898094 @default.
- W2019934240 creator A5018075041 @default.
- W2019934240 creator A5050052918 @default.
- W2019934240 date "2011-01-01" @default.
- W2019934240 modified "2023-10-01" @default.
- W2019934240 title "The stimulating adventure of KRN 7000" @default.
- W2019934240 cites W1527985047 @default.
- W2019934240 cites W1538172952 @default.
- W2019934240 cites W1542562398 @default.
- W2019934240 cites W1546988500 @default.
- W2019934240 cites W1568297835 @default.
- W2019934240 cites W1659136311 @default.
- W2019934240 cites W1748261727 @default.
- W2019934240 cites W1799419298 @default.
- W2019934240 cites W1801612364 @default.
- W2019934240 cites W1804629939 @default.
- W2019934240 cites W1828603026 @default.
- W2019934240 cites W1864648105 @default.
- W2019934240 cites W1879507323 @default.
- W2019934240 cites W1913627479 @default.
- W2019934240 cites W1956382842 @default.
- W2019934240 cites W1964940650 @default.
- W2019934240 cites W1965621413 @default.
- W2019934240 cites W1966204602 @default.
- W2019934240 cites W1966998421 @default.
- W2019934240 cites W1968884986 @default.
- W2019934240 cites W1969379272 @default.
- W2019934240 cites W1971066229 @default.
- W2019934240 cites W1971296979 @default.
- W2019934240 cites W1971330949 @default.
- W2019934240 cites W1972085567 @default.
- W2019934240 cites W1974936220 @default.
- W2019934240 cites W1975604260 @default.
- W2019934240 cites W1976690411 @default.
- W2019934240 cites W1976812883 @default.
- W2019934240 cites W1976899790 @default.
- W2019934240 cites W1977557930 @default.
- W2019934240 cites W1979727939 @default.
- W2019934240 cites W1980339601 @default.
- W2019934240 cites W1982102426 @default.
- W2019934240 cites W1983243890 @default.
- W2019934240 cites W1984260390 @default.
- W2019934240 cites W1985478950 @default.
- W2019934240 cites W1987904745 @default.
- W2019934240 cites W1987950952 @default.
- W2019934240 cites W1988574126 @default.
- W2019934240 cites W1989626793 @default.
- W2019934240 cites W1991083242 @default.
- W2019934240 cites W1991253497 @default.
- W2019934240 cites W1992523113 @default.
- W2019934240 cites W1997047110 @default.
- W2019934240 cites W2000653530 @default.
- W2019934240 cites W2002806364 @default.
- W2019934240 cites W2004122281 @default.
- W2019934240 cites W2004611408 @default.
- W2019934240 cites W2004687347 @default.
- W2019934240 cites W2005138940 @default.
- W2019934240 cites W2005758450 @default.
- W2019934240 cites W2006370829 @default.
- W2019934240 cites W2007137754 @default.
- W2019934240 cites W2007995597 @default.
- W2019934240 cites W2008075975 @default.
- W2019934240 cites W2011312724 @default.
- W2019934240 cites W2011484018 @default.
- W2019934240 cites W2012816635 @default.
- W2019934240 cites W2014433507 @default.
- W2019934240 cites W2014540590 @default.
- W2019934240 cites W2016003221 @default.
- W2019934240 cites W2016750734 @default.
- W2019934240 cites W2016764183 @default.
- W2019934240 cites W2017019788 @default.
- W2019934240 cites W2020397832 @default.
- W2019934240 cites W2020616438 @default.
- W2019934240 cites W2020693667 @default.
- W2019934240 cites W2026058426 @default.
- W2019934240 cites W2026554927 @default.
- W2019934240 cites W2026757577 @default.
- W2019934240 cites W2027263177 @default.
- W2019934240 cites W2028221734 @default.
- W2019934240 cites W2028452125 @default.
- W2019934240 cites W2031196319 @default.
- W2019934240 cites W2031783022 @default.
- W2019934240 cites W2033443495 @default.
- W2019934240 cites W2034986597 @default.
- W2019934240 cites W2035891945 @default.
- W2019934240 cites W2036850741 @default.
- W2019934240 cites W2037085755 @default.
- W2019934240 cites W2037980239 @default.
- W2019934240 cites W2038728857 @default.
- W2019934240 cites W2040843705 @default.
- W2019934240 cites W2041748137 @default.
- W2019934240 cites W2042162829 @default.
- W2019934240 cites W2042839372 @default.