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- W2019934780 abstract "Many recent data indicate that transport of Cl− across the ciliary epithelium plays an important role in aqueous humor formation. We used 36Cl to investigate the pathways for Cl−-transport in confluent monolayers of cultured bovine pigmented ciliary epithelial cells. Cl−-uptake mainly occurred via a mechanism with typical characteristics of an anion exchanger, and could be stimulated by an outwardly directed HCO3− gradient. One mm SITS and 1 mm DIDS inhibited Cl−, I− and Br−, by NO3−, formate and acetate. Inhibition of Cl− uptake by extracellular HCO3− was less effective in the absence of extracellular Na+, suggesting that not only HCO3− but also an action of loop-diuretics on the anion exchanger. 36Cl− uptake was cis-inhibited by the halides Cl−, I− and Br−, by NO3−, formate and acetate. Inhibition of Cl− uptake by extracellular HCO3− was less effective in the absence of extracellular Na+, suggesting that not only HCO3− but also NaCO3− binds to the carrier. SO42−, cyclamate and gluconate did not significantly reduce Cl− uptake via the anion exchanger. DIDS-sensitive Cl− uptake showed saturation kinetics with respect to the Cl− concentration with an apparent Km of 8 mm. Cl− efflux could be stimulated by external Cl− and HCO3− and was inhibited by DIDS. Thus, cultured bovine pigmented ciliary epithelial cells express a Cl−HCO3− exchanger. A possible role of this carrier system for aqueous humor formation is discussed." @default.
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- W2019934780 date "1988-10-01" @default.
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- W2019934780 title "Characterization of exchange in cultured bovine pigmented ciliary epithelium" @default.
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- W2019934780 doi "https://doi.org/10.1016/0014-4835(88)90091-7" @default.
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