Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019935012> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2019935012 endingPage "440" @default.
- W2019935012 startingPage "428" @default.
- W2019935012 abstract "A microsomal fraction prepared from rabbit lung tissue was found to catalyze CDPdiacylglycerol-independent incorporation of [3H]inositol into phosphatidylinositol. This incorporation resulted from CMP-dependent phosphatidylinositol-inositol exchange and did not constitute a net synthesis of phosphatidylinositol. The phosphatidylinositol-inositol exchange activity was distinct from the phospholipid-base exchange enzymes and was specific for inositol. Optimal in vitro phosphatidylinositol-inositol exchange activity was observed at pH 8.5–8.8 and either Mn2+ or Mg2+ was essential for activity. Mercaptoethanol stimulated phosphatidylinositol-inositol exchange and Hg2+ inhibited this activity. In the absence of CMP, no phosphatidylinositol-inositol exchange was observed. CDP (and to a smaller extent CTP) also supported phosphatidylinositol-inositol exchange and this appeared to occur via the generation of CMP during incubations. The apparent Km values of the phosphatidylinositol-inositol exchange enzyme for CMP and inositol were 0.4 mM and 11 μM, respectively. When CDPdiacylglycerol was present at a concentration optimal for CDPdiacylglycerol: inositol transferase activity, CMP-dependent phosphatidylinositol-inositol exchange activity was still observed. However, in the presence of Hg2+ CDPdiacylglycerol inhibited phosphatidylinositol-inositol exchange activity. Several properties of the phosphatidylinositol-inositol exchange enzyme resemble those of CDPdiacylglycerol: inositol transferase, but the two enzymes appear distinct on the basis of different degrees of inhibition by either Ca2+, Hg2+ or heat, and on the basis of different changes in activity during lung development." @default.
- W2019935012 created "2016-06-24" @default.
- W2019935012 creator A5028543972 @default.
- W2019935012 creator A5075329460 @default.
- W2019935012 date "1981-05-01" @default.
- W2019935012 modified "2023-09-25" @default.
- W2019935012 title "Phosphatidylinositol-inositol exchange in rabbit lung" @default.
- W2019935012 cites W12664899 @default.
- W2019935012 cites W1550437879 @default.
- W2019935012 cites W1584574994 @default.
- W2019935012 cites W1775749144 @default.
- W2019935012 cites W1924509623 @default.
- W2019935012 cites W1971690022 @default.
- W2019935012 cites W1984296511 @default.
- W2019935012 cites W1984732335 @default.
- W2019935012 cites W2000895386 @default.
- W2019935012 cites W2020220074 @default.
- W2019935012 cites W2024479106 @default.
- W2019935012 cites W2028051767 @default.
- W2019935012 cites W2037218214 @default.
- W2019935012 cites W2044167657 @default.
- W2019935012 cites W2072115891 @default.
- W2019935012 cites W2085000967 @default.
- W2019935012 cites W2128439230 @default.
- W2019935012 cites W2157936908 @default.
- W2019935012 cites W2164868165 @default.
- W2019935012 cites W2183131807 @default.
- W2019935012 cites W2344136256 @default.
- W2019935012 cites W4297935338 @default.
- W2019935012 doi "https://doi.org/10.1016/0005-2760(81)90065-5" @default.
- W2019935012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6264967" @default.
- W2019935012 hasPublicationYear "1981" @default.
- W2019935012 type Work @default.
- W2019935012 sameAs 2019935012 @default.
- W2019935012 citedByCount "24" @default.
- W2019935012 crossrefType "journal-article" @default.
- W2019935012 hasAuthorship W2019935012A5028543972 @default.
- W2019935012 hasAuthorship W2019935012A5075329460 @default.
- W2019935012 hasConcept C170493617 @default.
- W2019935012 hasConcept C181199279 @default.
- W2019935012 hasConcept C184235292 @default.
- W2019935012 hasConcept C185592680 @default.
- W2019935012 hasConcept C2777427919 @default.
- W2019935012 hasConcept C2778618036 @default.
- W2019935012 hasConcept C2780610907 @default.
- W2019935012 hasConcept C2781387506 @default.
- W2019935012 hasConcept C55493867 @default.
- W2019935012 hasConceptScore W2019935012C170493617 @default.
- W2019935012 hasConceptScore W2019935012C181199279 @default.
- W2019935012 hasConceptScore W2019935012C184235292 @default.
- W2019935012 hasConceptScore W2019935012C185592680 @default.
- W2019935012 hasConceptScore W2019935012C2777427919 @default.
- W2019935012 hasConceptScore W2019935012C2778618036 @default.
- W2019935012 hasConceptScore W2019935012C2780610907 @default.
- W2019935012 hasConceptScore W2019935012C2781387506 @default.
- W2019935012 hasConceptScore W2019935012C55493867 @default.
- W2019935012 hasIssue "2" @default.
- W2019935012 hasLocation W20199350121 @default.
- W2019935012 hasLocation W20199350122 @default.
- W2019935012 hasOpenAccess W2019935012 @default.
- W2019935012 hasPrimaryLocation W20199350121 @default.
- W2019935012 hasRelatedWork W144036542 @default.
- W2019935012 hasRelatedWork W1977769302 @default.
- W2019935012 hasRelatedWork W1980842369 @default.
- W2019935012 hasRelatedWork W2014820467 @default.
- W2019935012 hasRelatedWork W2024831120 @default.
- W2019935012 hasRelatedWork W2033794765 @default.
- W2019935012 hasRelatedWork W2034507683 @default.
- W2019935012 hasRelatedWork W2043672273 @default.
- W2019935012 hasRelatedWork W2063903820 @default.
- W2019935012 hasRelatedWork W2238525991 @default.
- W2019935012 hasVolume "664" @default.
- W2019935012 isParatext "false" @default.
- W2019935012 isRetracted "false" @default.
- W2019935012 magId "2019935012" @default.
- W2019935012 workType "article" @default.