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• W2019935431 abstract "Sedimentation velocity separation of Rhesus monkey bone marrow cells has demonstrated a reproducible but heterogeneous size distribution of cells capable of forming granulocytic colonies in agar culture (CFC's). This heterogeneity is shown to be due to the cell cycle status of the progenitor cell population. In vitro exposure of bone marrow cells to lethal doses of tritiated thymidine (H3TdR) either before or after separation restricts the size distribution of CFC's, greatly reducing the proportion of rapidly sedimenting cells. The calculation of the volume distribution of such cells before and after H3TdR exposure indicates that 55% of total CFC's in adult marrow are in G0 or G1 with a volume of 410 μ3, 42% are in S phase and of volume 450–950 μ3, and the remainder are in G2 and mitosis with a volume of between 600–950 μ3. CFC's in mid gestation fetal liver were larger than their adult counterparts and were of homogeneous volume indicative of a single non cycling population with no evidence of an S or G2 component. H3TdR exposure confirmed the non-cycling status of these fetal progenitor cells." @default.
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• W2019935431 date "1973-08-01" @default.
• W2019935431 modified "2023-09-24" @default.
• W2019935431 title "Sedimentation velocity characterisation of the cell cycle of granulocytic progenitor cells in monkey hemopoietic tissue" @default.
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• W2019935431 doi "https://doi.org/10.1002/jcp.1040820110" @default.
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