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• W2019936255 abstract "Arecoline is the main alkaloid present in the areca nut (or betel nut) and it has central nervous system effects. Its pharmacological activities induce the constriction of the bronchial smooth muscles, and stimulation of the lacrimal and intestinal glands. Chewing areca nut is harmful to health because this habit may increase the risk of the development of oral cancer. In this study, a fast method was provided for the determination of areca alkaloids by matrix-assisted laser desorption ionization (MALDI) mass spectrometer with a time-of-flight (TOF) analyzer. Traditionally the MALDI-TOF method was not suitable for the analysis of small molecular weight (m/z < 600) compounds because of the high background of the matrix. In this study, a new matrix was utilized to decrease the background interference effectively. After simple sample preparation, 1 μL sample supernatant was mixed with 1 μL matrix and then deposited on the target plate. This new matrix was also used to test the MALDI imaging experiment. Application of this MALDI-TOF method for trace analysis of arecoline by this new matrix in human plasma at sub μM level proved workable." @default.
• W2019936255 created "2016-06-24" @default.
• W2019936255 creator A5004929372 @default.
• W2019936255 creator A5041203336 @default.
• W2019936255 date "2009-09-01" @default.
• W2019936255 modified "2023-09-24" @default.
• W2019936255 title "A new matrix for analyzing low molecular mass compounds and its application for determination of carcinogenic areca alkaloids by matrix-assisted laser desorption ionization time-of-flight mass spectrometry" @default.
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• W2019936255 doi "https://doi.org/10.1016/j.aca.2009.07.039" @default.
• W2019936255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19699399" @default.
• W2019936255 hasPublicationYear "2009" @default.
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