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- W2019936333 abstract "Abstract Effects of aminodipropionitrile (ADPN) on behavior, locomotor activity, food consumption, body weights and endocrine function were noted in male albino mice (CFW). Six daily, consecutive intraperitoneal injections of the drug caused hyperactivity and behavioral phenomena which resembled the circling and headshaking syndrome observed in mutant waltzing mice. Two dose levels 1.0 and 1.5 g/kg were administered to the test groups. Control animals received normal saline. All mice were sacrificed at the end of one week, 48 hr after the 6th and final injection. At both dose levels, the findings revealed significant decreases in body weights, food consumption, food utilization and fecal excretion with consistently more pronounced effects being caused by the 1.5 g/kg dose. Significant increases were noted in the locomotor activity and circling activity of the test mice. Total WBC counts were significantly decreased and adrenal ascorbic acid content/gland significantly increased in the test groups. These findings together with increases in the relative adrenal weights and decreases in the thymus and spleen weights indicated significantly increased pituitary-adrenocortical activity in the test mice. Significant decreases in the seminal vesicle weights of the test vs. control mice suggested hypogonadism. The various data while in accordance with nonspecific stress, also demonstrated certain similarities and parallelisms to behavioral patterns and endocrine activities in the mutant waltzing (whirler) stock." @default.
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- W2019936333 date "1973-03-01" @default.
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- W2019936333 title "Behavioral and endocrine effects of aminodipropionitrile (ADPN) in male mice" @default.
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- W2019936333 doi "https://doi.org/10.1016/0091-3057(73)90098-1" @default.
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