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- W2019936454 abstract "The most challenging problem in cancer therapy is tumor resistance to treatment modalities, such as radiation and chemotherapy. There exist two types of resistance to DNA damage-inducing agents: first, naturally occurring resistance and, second, therapy-induced resistance. Advances in understanding the molecular mechanism that regulates the DNA damage-signaling pathway makes it possible to better define the key regulatory targets involving the development of tumor resistance. In this brief report, we summarize the recent advances in DNA damage signaling, and discuss the potential targets for drug development and better design of clinical trials for cancer patients, especially those with lung cancer." @default.
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- W2019936454 title "Lung cancer drug resistance and DNA damage signaling" @default.
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