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- W2019936739 abstract "A novel solid support 1 was synthesized to incorporate glyoxylic aldehyde functionality at the oligonucleotide 3‘-terminus. 6-mer and 11-mer oligonucleotide sequences containing 3‘-glyoxylic aldehyde functionality were prepared by using this support. These modified oligonucleotides were coupled to reporters containing an aminooxy group to prepare oligonucleotide 3‘-conjugates through glyoxylic oxime bond formation. The hydrolytic stability of a glyoxylic oxime linkage was also investigated." @default.
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- W2019936739 date "2006-12-21" @default.
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- W2019936739 title "New Solid Support for the Synthesis of 3‘-Oligonucleotide Conjugates through Glyoxylic Oxime Bond Formation" @default.
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- W2019936739 doi "https://doi.org/10.1021/ol062607b" @default.
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