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- W2019937851 abstract "Summary. Helical strips of saphenous veins from diabetic (n=8) and non-diabetic (n= 18) humans were studied in vivo for their responsiveness to several vasoactive agents. Following application of passive force (˜20·0 mN), venous strips from non-diabetic humans often developed spontaneous phasic contractile activity (12 out of 18 patients; 2–5 contractions/min). These intrinsic changes in force were seen in venous strips from only one diabetic patient. The phasic contractions were not altered by treatment with phentolamine, whereas the calcium channel blocker, D-600, and calcium-free solution (1·0 mM EGTA) inhibited the phasic contractions. Saphenous veins from diabetic patients developed less maximal, active tension in response to norepinephrine than those from non-diabetic patients. Contractile responses to serotonin, angiotensin II, and elevated potassium concentration in saphenous veins from diabetic patients were not different from those in veins from non-diabetic patients. These observations demonstrate attenuated development of active tension in response to alpha-adrenergic receptor activation and reduced spontaneous contractile activity in venous smooth muscle from diabetic patients." @default.
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- W2019937851 date "1984-12-01" @default.
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- W2019937851 title "Diabetes and reactivity of isolated human saphenous vein" @default.
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- W2019937851 doi "https://doi.org/10.1111/j.1475-097x.1984.tb00136.x" @default.
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