FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019938294> ?p ?o ?g. }

• W2019938294 endingPage "e104318" @default.
• W2019938294 startingPage "e104318" @default.
• W2019938294 abstract "Neurons producing serotonin (5-hydroxytryptamine, 5-HT) constitute one of the most widely distributed neuronal networks in the mammalian central nervous system (CNS) and exhibit a profuse innervation throughout the CNS already at early stages of development. Serotonergic neuron specification is controlled by a combination of secreted molecules and transcription factors such as Shh, Fgf4/8, Nkx2.2, Lmx1b and Pet1. In the mouse, Pet1 mRNA expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (Tph2) and serotonin transporter (SERT). Hence, the generation of genetic tools based on Pet1 specific expression represents a valuable approach to study the development and function of the serotonergic system. Here, we report the generation of a Pet1(210)-Cre transgenic mouse line in which the Cre recombinase is expressed under the control of a 210 kb fragment from the Pet1 genetic locus to ensure a reliable and faithful control of somatic recombination in Pet1 cell lineage. Besides Cre-mediated recombination accurately occurred in the serotonergic system as expected and according to previous studies, Pet1(210)-Cre transgenic mouse line allowed us to identify novel, so far uncharacterized, Pet1 expression domains. Indeed, we showed that in the raphe Pet1 is expressed also in a non-serotonergic neuronal population intermingled with Tph2-expressing cells and mostly localized in the B8 and B9 nuclei. Moreover, we detected Cre-mediated recombination also in the developing pancreas and in the ureteric bud derivatives of the kidney, where it reflected a specific Pet1 expression. Thus, Pet1(210)-Cre transgenic mouse line faithfully drives Cre-mediated recombination in all Pet1 expression domains representing a valuable tool to genetically manipulate serotonergic and non-serotonergic Pet1 cell lineages." @default.
• W2019938294 created "2016-06-24" @default.
• W2019938294 creator A5002710894 @default.
• W2019938294 creator A5031642285 @default.
• W2019938294 creator A5036471912 @default.
• W2019938294 creator A5049205245 @default.
• W2019938294 creator A5068253917 @default.
• W2019938294 date "2014-08-06" @default.
• W2019938294 modified "2023-09-25" @default.
• W2019938294 title "Generation of Pet1210-Cre Transgenic Mouse Line Reveals Non-Serotonergic Expression Domains of Pet1 Both in CNS and Periphery" @default.
• W2019938294 cites W1511435402 @default.
• W2019938294 cites W1556520758 @default.
• W2019938294 cites W1630907922 @default.
• W2019938294 cites W1768274470 @default.
• W2019938294 cites W1831469814 @default.
• W2019938294 cites W1929691281 @default.
• W2019938294 cites W1969194398 @default.
• W2019938294 cites W1976494054 @default.
• W2019938294 cites W1977995035 @default.
• W2019938294 cites W1980168859 @default.
• W2019938294 cites W1985057945 @default.
• W2019938294 cites W1986713296 @default.
• W2019938294 cites W1987083929 @default.
• W2019938294 cites W1990454576 @default.
• W2019938294 cites W1994918767 @default.
• W2019938294 cites W1996733770 @default.
• W2019938294 cites W1998591058 @default.
• W2019938294 cites W1999488803 @default.
• W2019938294 cites W2003123999 @default.
• W2019938294 cites W2004207259 @default.
• W2019938294 cites W2005713680 @default.
• W2019938294 cites W2005950756 @default.
• W2019938294 cites W2007077740 @default.
• W2019938294 cites W2008205503 @default.
• W2019938294 cites W2013740680 @default.
• W2019938294 cites W2014711343 @default.
• W2019938294 cites W2017400430 @default.
• W2019938294 cites W2018419775 @default.
• W2019938294 cites W2018826263 @default.
• W2019938294 cites W2031897279 @default.
• W2019938294 cites W2038174426 @default.
• W2019938294 cites W2044806898 @default.
• W2019938294 cites W2045283840 @default.
• W2019938294 cites W2045290451 @default.
• W2019938294 cites W2047819219 @default.
• W2019938294 cites W2052784390 @default.
• W2019938294 cites W2054212910 @default.
• W2019938294 cites W2055466946 @default.
• W2019938294 cites W2071376194 @default.
• W2019938294 cites W2075464370 @default.
• W2019938294 cites W2076107852 @default.
• W2019938294 cites W2080466336 @default.
• W2019938294 cites W2080987963 @default.
• W2019938294 cites W2081784716 @default.
• W2019938294 cites W2083166335 @default.
• W2019938294 cites W2098331502 @default.
• W2019938294 cites W2099652166 @default.
• W2019938294 cites W2104741209 @default.
• W2019938294 cites W2106218592 @default.
• W2019938294 cites W2109627278 @default.
• W2019938294 cites W2121508096 @default.
• W2019938294 cites W2130358596 @default.
• W2019938294 cites W2139148195 @default.
• W2019938294 cites W2144212283 @default.
• W2019938294 cites W2149678354 @default.
• W2019938294 cites W2149882695 @default.
• W2019938294 cites W2150013759 @default.
• W2019938294 cites W2150247056 @default.
• W2019938294 cites W2152069082 @default.
• W2019938294 cites W2157616236 @default.
• W2019938294 cites W2167244529 @default.
• W2019938294 cites W2171786302 @default.
• W2019938294 cites W2172296786 @default.
• W2019938294 cites W2180812410 @default.
• W2019938294 cites W2317783677 @default.
• W2019938294 cites W2334366741 @default.
• W2019938294 cites W4253484688 @default.
• W2019938294 cites W57548255 @default.
• W2019938294 doi "https://doi.org/10.1371/journal.pone.0104318" @default.
• W2019938294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4123907" @default.
• W2019938294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25098329" @default.
• W2019938294 hasPublicationYear "2014" @default.
• W2019938294 type Work @default.
• W2019938294 sameAs 2019938294 @default.
• W2019938294 citedByCount "36" @default.
• W2019938294 countsByYear W20199382942015 @default.
• W2019938294 countsByYear W20199382942016 @default.
• W2019938294 countsByYear W20199382942017 @default.
• W2019938294 countsByYear W20199382942018 @default.
• W2019938294 countsByYear W20199382942019 @default.
• W2019938294 countsByYear W20199382942020 @default.
• W2019938294 countsByYear W20199382942021 @default.
• W2019938294 countsByYear W20199382942022 @default.
• W2019938294 crossrefType "journal-article" @default.
• W2019938294 hasAuthorship W2019938294A5002710894 @default.
• W2019938294 hasAuthorship W2019938294A5031642285 @default.
• W2019938294 hasAuthorship W2019938294A5036471912 @default.
• W2019938294 hasAuthorship W2019938294A5049205245 @default.

• next