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- W2019938557 abstract "Abstract The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) has a low-to-moderate toxicity in animals; however, high doses of 2,4,5-T have been shown to cause various toxic effects in mammals. Although this compound can be rapidly eliminated from the body by renal transport, there are circumstances wherein large amounts of this compound persist in the plasma and are accumulated by the kidney for prolonged periods of time. In order to determine the nature of this retention, 2,4,5-T binding to plasma proteins and renal tissue has been examined. The present results indicate that 2,4,5-T is bound extensively to plasma protein which could limit renal clearance of the herbicide. In addition, 2,4,5-T is bound to the microsomal and cytosol fractions of the renal cortex. One site has been found for 2,4,5-T binding to the microsomes. This site has an association constant (Ka) of 2.4 × 103 m −1 and a binding capacity (n) of 17.5 μmol/g protein. Two 2,4,5-T binding sites have been found for the cytosol fraction. The first is a high affinity (Ka1 = 1.5 × 104 m −1) and low capacity (n1 = 4.48 μmol/g protein) site, while the second is a low affinity (Ka2 = 0.04 × 103 m −1) and high capacity (n2 = 630 μmol/g protein) site. These renal binding sites could explain the retention of 2,4,5-T in the kidney and may play a role in the nephrotoxicity of this herbicide." @default.
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- W2019938557 date "1979-06-01" @default.
- W2019938557 modified "2023-09-24" @default.
- W2019938557 title "Serum protein and renal tissue binding of 2,4,5-trichlorophenoxyacetic acid" @default.
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- W2019938557 doi "https://doi.org/10.1016/0041-008x(79)90246-1" @default.
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