FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019938767> ?p ?o ?g. }

• W2019938767 endingPage "e40301" @default.
• W2019938767 startingPage "e40301" @default.
• W2019938767 abstract "Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis, and is induced by TGF-β. Here we examined whether an anti-fibrotic agent, N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP), can regulate induction of TGF-β signaling and myofibroblast differentiation as a potential key component of its anti-fibrotic mechanism in vivo and in vitro.Rat pulmonary fibroblasts were cultured in vitro and divided to 4 groups 1) control; 2) TGF-β1; 3) TGF-β1+ LY364947; 4) TGF-β1+Ac-SDKP. For in vivo studies, six groups of animals were utilized 1) control 4w; 2) silicotic 4w; 3) control 8w; 4) silicotic 8w; 5) Ac-SDKP post-treatment; 6)Ac-SDKP pre-treatment. SiO(2) powders were douched in the trachea of rat to make the silicotic model. Myofibroblast differentiation was measured by examining expression of α-SMA, as well as expression of serum response factor (SRF), a key regulator of myofibroblast differentiation. The expressions of collagen, TGF-β1 and RAS signaling were also assessed. The results revealed that TGF-β1 strongly induced myofibroblast differentiation and collagen synthesis in vitro, and that pre-treatment with Ac-SDKP markedly attenuated myofibroblast activation, as well as induction of TGF-β1 and its receptor. Similar results were observed in vivo in the pathologically relevant rat model of silicosis. Ac-SDKP treatment in vivo strongly attenuated 1) silicosis-induced increased expressions of TGF-β1 and RAS signaling, 2) myofibroblast differentiation as indicated by a robust decrease of SRF and α-SMA-positive myofibroblast localization in siliconic nodules in the lung, 3) collagen deposition.The results of the present study suggest a novel mechanism of action for Ac-SDKP's beneficial effect in silicosis, which involves attenuation of TGF-β1 and its receptors, SRF and Ang II type 1 receptor (AT(1)) expression, collagen deposition and myofibroblast differentiation. The results further suggest that therapies targeting myofibroblast differentiation may have therapeutic efficacy in treatment of silicosis of the lung." @default.
• W2019938767 created "2016-06-24" @default.
• W2019938767 creator A5007165393 @default.
• W2019938767 creator A5011540763 @default.
• W2019938767 creator A5014351098 @default.
• W2019938767 creator A5015578891 @default.
• W2019938767 creator A5021806183 @default.
• W2019938767 creator A5027076878 @default.
• W2019938767 creator A5042567804 @default.
• W2019938767 creator A5058886370 @default.
• W2019938767 creator A5065278090 @default.
• W2019938767 creator A5071261595 @default.
• W2019938767 date "2012-07-03" @default.
• W2019938767 modified "2023-10-09" @default.
• W2019938767 title "A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis" @default.
• W2019938767 cites W132650780 @default.
• W2019938767 cites W1505584712 @default.
• W2019938767 cites W1855762846 @default.
• W2019938767 cites W1964081206 @default.
• W2019938767 cites W1969049128 @default.
• W2019938767 cites W1972221458 @default.
• W2019938767 cites W1981828551 @default.
• W2019938767 cites W1983695586 @default.
• W2019938767 cites W1993493586 @default.
• W2019938767 cites W1994572818 @default.
• W2019938767 cites W1994798254 @default.
• W2019938767 cites W2035653659 @default.
• W2019938767 cites W2052532100 @default.
• W2019938767 cites W2058225109 @default.
• W2019938767 cites W2071038507 @default.
• W2019938767 cites W2082837373 @default.
• W2019938767 cites W2084689397 @default.
• W2019938767 cites W2100326545 @default.
• W2019938767 cites W2104002497 @default.
• W2019938767 cites W2108806591 @default.
• W2019938767 cites W2117094361 @default.
• W2019938767 cites W2117200840 @default.
• W2019938767 cites W2119380135 @default.
• W2019938767 cites W2126168922 @default.
• W2019938767 cites W2131921930 @default.
• W2019938767 cites W2135136127 @default.
• W2019938767 cites W2151381771 @default.
• W2019938767 cites W2151786051 @default.
• W2019938767 cites W2153324184 @default.
• W2019938767 cites W2154589460 @default.
• W2019938767 cites W2167768045 @default.
• W2019938767 cites W2170555676 @default.
• W2019938767 cites W2171030174 @default.
• W2019938767 cites W2172011106 @default.
• W2019938767 cites W2188064034 @default.
• W2019938767 cites W2415518998 @default.
• W2019938767 cites W2470735264 @default.
• W2019938767 cites W4249341602 @default.
• W2019938767 doi "https://doi.org/10.1371/journal.pone.0040301" @default.
• W2019938767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3389005" @default.
• W2019938767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22802960" @default.
• W2019938767 hasPublicationYear "2012" @default.
• W2019938767 type Work @default.
• W2019938767 sameAs 2019938767 @default.
• W2019938767 citedByCount "61" @default.
• W2019938767 countsByYear W20199387672013 @default.
• W2019938767 countsByYear W20199387672014 @default.
• W2019938767 countsByYear W20199387672015 @default.
• W2019938767 countsByYear W20199387672016 @default.
• W2019938767 countsByYear W20199387672017 @default.
• W2019938767 countsByYear W20199387672018 @default.
• W2019938767 countsByYear W20199387672019 @default.
• W2019938767 countsByYear W20199387672020 @default.
• W2019938767 countsByYear W20199387672021 @default.
• W2019938767 countsByYear W20199387672022 @default.
• W2019938767 countsByYear W20199387672023 @default.
• W2019938767 crossrefType "journal-article" @default.
• W2019938767 hasAuthorship W2019938767A5007165393 @default.
• W2019938767 hasAuthorship W2019938767A5011540763 @default.
• W2019938767 hasAuthorship W2019938767A5014351098 @default.
• W2019938767 hasAuthorship W2019938767A5015578891 @default.
• W2019938767 hasAuthorship W2019938767A5021806183 @default.
• W2019938767 hasAuthorship W2019938767A5027076878 @default.
• W2019938767 hasAuthorship W2019938767A5042567804 @default.
• W2019938767 hasAuthorship W2019938767A5058886370 @default.
• W2019938767 hasAuthorship W2019938767A5065278090 @default.
• W2019938767 hasAuthorship W2019938767A5071261595 @default.
• W2019938767 hasBestOaLocation W20199387671 @default.
• W2019938767 hasConcept C118131993 @default.
• W2019938767 hasConcept C142724271 @default.
• W2019938767 hasConcept C150903083 @default.
• W2019938767 hasConcept C185592680 @default.
• W2019938767 hasConcept C203014093 @default.
• W2019938767 hasConcept C207001950 @default.
• W2019938767 hasConcept C207865475 @default.
• W2019938767 hasConcept C2777811718 @default.
• W2019938767 hasConcept C2780559512 @default.
• W2019938767 hasConcept C2781244666 @default.
• W2019938767 hasConcept C71924100 @default.
• W2019938767 hasConcept C86803240 @default.
• W2019938767 hasConcept C95444343 @default.
• W2019938767 hasConceptScore W2019938767C118131993 @default.
• W2019938767 hasConceptScore W2019938767C142724271 @default.

• next