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- W2019939191 abstract "Many N,N-dialkylated tryptamine derivatives can induce altered states ofconsciousness in humans. The term ‘‘hallucinogen’’ is often used when de-scribing the effect on the human mind, and the extent of psychoactivitydepends on the nature of substituents attached to the ethylamine side chainand the indole ring. Naturally-occurring tryptamines (e.g., N,N-dimethyl-tryptamine and psilocybin) have increasingly been investigated in humanclinical studies, which increased interest within a number of scientificcommunities and the public. Many of these derivatives are controlled sub-stances and an increasing number of previously unreported and structurallymodified N,N-dialkylated ‘‘designer’’ tryptamines with unknown bioactiveprofiles have become available.This review provides an overview of analytical methodologies published inrecent years on detection and characterization of 40 N,N-dialkylated deri-vatives. The majority of literature available utilized reversed-phase high-performance liquid chromatography, gas chromatography and/or capillaryelectrophoresis. Derivatization was not normally required for sufficient se-paration and detection.Bioanalytical applications and characterization of natural products havenot been included due to space limitations. The majority of analytical datadescribed in the literature indicated the dominance of N,N-dialkylatedderivatives carrying a methoxy group or hydrogen at the 5-position of theindole ring. A consistent body of data has been produced and should set thescene for the detection of derivatives in order to inform healthcare providers,clinicians, forensic scientists and potential consumers.a 2010 Elsevier Ltd. All rights reserved." @default.
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- W2019939191 date "2010-09-01" @default.
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- W2019939191 title "Analytical methods for psychoactive N,N-dialkylated tryptamines" @default.
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