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- W2019939708 abstract "Interleukin-4 receptor (IL-4R) is the cell surface complex through which interleukin-4 (IL-4) signals exert its critical biological effects. The α-chain of IL-4R is responsible for the high affinity binding of IL-4. In this report, is characterized, the 5′ untranslated flanking region of murine IL-4Rα gene in the Th2 clone D10.G4.1. We have analyzed a DNA fragment spanning from −995 to +84 relative to the transcription start point. Mutagenesis analysis shows that, neither the previously described Stat6 (–395) nor the NFAT (−266) and NFκB (+25) sequences localized here, are involved in the IL-4Rα promoter activity. Reporter assays demonstrate that maximum transcriptional activity is achieved by the −89 to +84 sequence and this activity is independent of a TATA-like box located at −25. We have identified a GT box located at −45 as the critical element for the IL-4Rα promoter activity. Experiments in SL2 cells, which lack endogenous Sp proteins, show that IL-4Rα minimal promoter is transactivated by proteins of Sp family." @default.
- W2019939708 created "2016-06-24" @default.
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- W2019939708 date "2006-04-01" @default.
- W2019939708 modified "2023-10-14" @default.
- W2019939708 title "The activity of interleukin-4 receptor α-chain promoter is regulated by a GT box element" @default.
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- W2019939708 doi "https://doi.org/10.1016/j.molimm.2005.10.016" @default.
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