Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019940052> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2019940052 endingPage "90" @default.
- W2019940052 startingPage "87" @default.
- W2019940052 abstract "Using virus grown in monkey kidney cells, Salk and his colleagues developed an inactivated poliovirus vaccine (IPV) in 1952. A large-scale field trial showed the vaccine to be safe and highly immunogenic in children, but soon after the vaccine became generally available in 1955, cases of paralytic disease were reported in recipients. Investigations showed that almost all the cases occurred in children who had received vaccine from one particular manufacturer. Extensive studies attributed the disaster to problems with inactivation. Addition of a Seitz filtration step midway during formalin inactivation and extension of the inactivation period resulted in a safe vaccine. No further paralytic cases were observed following the use of several hundred million doses of this improved vaccine. Thus, IPV was safe and caused a dramatic decline in the incidence of poliomyelitis in countries where it was used. A second generation IPV is produced in fermentors using well-characterized cell strains or continuous cell lines. The major breakthrough in the development of live poliovirus vaccine was the application of tissue culture methods for virus attenuation. By 1959 several candidate live oral poliovirus vaccines (OPV) had been developed. These were clinically tested in millions of individuals and found to be safe and effective. Since the attenuated virus strains developed by Koprowski and Cox were more neurotropic in monkeys than the Sabin strains, only the latter was licensed in the USA in 1961 and endorsed shortly after by the World Health Organization (WHO). The widespread use of Sabin's OPV in many countries hastened the development of International Requirements by WHO for OPV in 1962 to define the criteria that ensured the uniformity of batches produced by different manufacturers. These have been updated continuously in light of new information and quality control procedures. Extensive field trials have shown the risk of OPV associated polio to be less than 0.3 per million doses administered." @default.
- W2019940052 created "2016-06-24" @default.
- W2019940052 creator A5001199593 @default.
- W2019940052 date "2006-06-01" @default.
- W2019940052 modified "2023-09-23" @default.
- W2019940052 title "Developments in the production and quality control of poliovirus vaccines – Historical perspectives" @default.
- W2019940052 cites W2010653647 @default.
- W2019940052 cites W2020018135 @default.
- W2019940052 cites W2034839075 @default.
- W2019940052 cites W2044910618 @default.
- W2019940052 cites W2068972530 @default.
- W2019940052 cites W2082554105 @default.
- W2019940052 cites W2098152450 @default.
- W2019940052 cites W2098796879 @default.
- W2019940052 cites W2158307330 @default.
- W2019940052 doi "https://doi.org/10.1016/j.biologicals.2006.02.008" @default.
- W2019940052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16621594" @default.
- W2019940052 hasPublicationYear "2006" @default.
- W2019940052 type Work @default.
- W2019940052 sameAs 2019940052 @default.
- W2019940052 citedByCount "23" @default.
- W2019940052 countsByYear W20199400522012 @default.
- W2019940052 countsByYear W20199400522013 @default.
- W2019940052 countsByYear W20199400522014 @default.
- W2019940052 countsByYear W20199400522016 @default.
- W2019940052 countsByYear W20199400522017 @default.
- W2019940052 countsByYear W20199400522019 @default.
- W2019940052 countsByYear W20199400522020 @default.
- W2019940052 countsByYear W20199400522023 @default.
- W2019940052 crossrefType "journal-article" @default.
- W2019940052 hasAuthorship W2019940052A5001199593 @default.
- W2019940052 hasConcept C104317684 @default.
- W2019940052 hasConcept C159047783 @default.
- W2019940052 hasConcept C203014093 @default.
- W2019940052 hasConcept C2522874641 @default.
- W2019940052 hasConcept C2776872762 @default.
- W2019940052 hasConcept C2779631682 @default.
- W2019940052 hasConcept C2908689829 @default.
- W2019940052 hasConcept C4870876 @default.
- W2019940052 hasConcept C54602769 @default.
- W2019940052 hasConcept C55493867 @default.
- W2019940052 hasConcept C60987743 @default.
- W2019940052 hasConcept C71924100 @default.
- W2019940052 hasConcept C86803240 @default.
- W2019940052 hasConceptScore W2019940052C104317684 @default.
- W2019940052 hasConceptScore W2019940052C159047783 @default.
- W2019940052 hasConceptScore W2019940052C203014093 @default.
- W2019940052 hasConceptScore W2019940052C2522874641 @default.
- W2019940052 hasConceptScore W2019940052C2776872762 @default.
- W2019940052 hasConceptScore W2019940052C2779631682 @default.
- W2019940052 hasConceptScore W2019940052C2908689829 @default.
- W2019940052 hasConceptScore W2019940052C4870876 @default.
- W2019940052 hasConceptScore W2019940052C54602769 @default.
- W2019940052 hasConceptScore W2019940052C55493867 @default.
- W2019940052 hasConceptScore W2019940052C60987743 @default.
- W2019940052 hasConceptScore W2019940052C71924100 @default.
- W2019940052 hasConceptScore W2019940052C86803240 @default.
- W2019940052 hasIssue "2" @default.
- W2019940052 hasLocation W20199400521 @default.
- W2019940052 hasLocation W20199400522 @default.
- W2019940052 hasOpenAccess W2019940052 @default.
- W2019940052 hasPrimaryLocation W20199400521 @default.
- W2019940052 hasRelatedWork W1966511352 @default.
- W2019940052 hasRelatedWork W1981373719 @default.
- W2019940052 hasRelatedWork W1989581564 @default.
- W2019940052 hasRelatedWork W2021506055 @default.
- W2019940052 hasRelatedWork W2073147981 @default.
- W2019940052 hasRelatedWork W2334777759 @default.
- W2019940052 hasRelatedWork W2412418278 @default.
- W2019940052 hasRelatedWork W2419370304 @default.
- W2019940052 hasRelatedWork W275045504 @default.
- W2019940052 hasRelatedWork W4292162885 @default.
- W2019940052 hasVolume "34" @default.
- W2019940052 isParatext "false" @default.
- W2019940052 isRetracted "false" @default.
- W2019940052 magId "2019940052" @default.
- W2019940052 workType "article" @default.