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- W2019940358 abstract "With benzyl alcohol as the varied substrate, sorbinil was found to be a competitive inhibitor of aldose reductase, an enzyme implicated in the etiology of secondary diabetic complications. The K(is sorbinil) and the Vmax/Km (V/K) benzyl alcohol decreased at low pH with a pK of 7.5 and 7.7, respectively. These observations suggest that both sorbinil and benzyl alcohol bind to the same site on the enzyme. Active site inhibition by sorbinil is consistent with non-competitive inhibition patterns of sorbinil with nucleotide coenzyme or aldehyde as the varied substrate in the direction of aldehyde reduction." @default.
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- W2019940358 date "1992-12-01" @default.
- W2019940358 modified "2023-09-25" @default.
- W2019940358 title "Does sorbinil bind to the substrate binding site of aldose reductase?" @default.
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- W2019940358 doi "https://doi.org/10.1016/0006-2952(92)90693-d" @default.
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