FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019940630> ?p ?o ?g. }

• W2019940630 endingPage "461" @default.
• W2019940630 startingPage "456" @default.
• W2019940630 abstract "A liver-specific transporter organic anion transporting polypeptide 1B1 (OATP1B1, also known as OATP-C) is encoded by SLCO1B1 and mediates uptake of various endogenous and exogenous compounds from blood into hepatocytes. In this study, 15 SLCO1B1 exons (including non-coding exon 1) and their flanking introns were comprehensively screened for genetic variations in 177 Japanese subjects. Sixty-two genetic variations, including 28 novel ones, were found: 7 in the 5'-flanking region, 1 in the 5'-untranslated region (UTR), 13 in the coding exons (9 nonsynonymous and 4 synonymous variations), 5 in the 3'-UTR, and 36 in the introns. Five novel nonsynonymous variations, 311T>A (Met104Lys), 509T>C (Met170Thr), 601A>G (Lys201Glu), 1553C>T (Ser518Leu), and 1738C>T (Arg580Stop), were found as heterozygotes. The allele frequencies were 0.008 for 1738C>T (Arg580Stop) and 0.003 for the four other variations. Arg580Stop having a stop codon at codon 580 results in loss of half of transmembrane domain (TMD) 11, TMD12, and a cytoplasmic tail, which might affect transport activity. In addition, novel variations, IVS12-1G>T at the splice acceptor site and -3A > C in the Kozak motif, were detected at 0.003 and 0.014 frequencies, respectively. Haplotype analysis using -11187G>A, -3A>C, IVS12-1G>T and 9 nonsynonymous variations revealed that the haplotype frequencies for *1b, *5, *15, and *17 were 0.469, 0.000 (not detected), 0.037, and 0.133, respectively. These data would provide fundamental and useful information for pharmacogenetic studies on OATP1B1-transported drugs in Japanese." @default.
• W2019940630 created "2016-06-24" @default.
• W2019940630 creator A5000894813 @default.
• W2019940630 creator A5002075588 @default.
• W2019940630 creator A5012223457 @default.
• W2019940630 creator A5017255080 @default.
• W2019940630 creator A5024904484 @default.
• W2019940630 creator A5030517670 @default.
• W2019940630 creator A5030587345 @default.
• W2019940630 creator A5031155500 @default.
• W2019940630 creator A5034287641 @default.
• W2019940630 creator A5037177984 @default.
• W2019940630 creator A5050855780 @default.
• W2019940630 creator A5057200745 @default.
• W2019940630 creator A5058549884 @default.
• W2019940630 creator A5072348333 @default.
• W2019940630 creator A5074846489 @default.
• W2019940630 creator A5079864042 @default.
• W2019940630 creator A5082354025 @default.
• W2019940630 creator A5089137663 @default.
• W2019940630 creator A5089211172 @default.
• W2019940630 creator A5090846902 @default.
• W2019940630 date "2007-01-01" @default.
• W2019940630 modified "2023-10-06" @default.
• W2019940630 title "Genetic Variations and Frequencies of Major Haplotypes in SLCO1B1 Encoding the Transporter OATP1B1 in Japanese Subjects: SLCO1B1*17 is More Prevalent Than *15" @default.
• W2019940630 cites W1978006382 @default.
• W2019940630 cites W1986885996 @default.
• W2019940630 cites W1993088391 @default.
• W2019940630 cites W2000484916 @default.
• W2019940630 cites W2008077160 @default.
• W2019940630 cites W2020828649 @default.
• W2019940630 cites W2024214969 @default.
• W2019940630 cites W2025416665 @default.
• W2019940630 cites W2025760569 @default.
• W2019940630 cites W2039141364 @default.
• W2019940630 cites W2039986849 @default.
• W2019940630 cites W2057385204 @default.
• W2019940630 cites W2061003736 @default.
• W2019940630 cites W2061481904 @default.
• W2019940630 cites W2076385318 @default.
• W2019940630 cites W2081656085 @default.
• W2019940630 cites W2139121124 @default.
• W2019940630 cites W4323053695 @default.
• W2019940630 doi "https://doi.org/10.2133/dmpk.22.456" @default.
• W2019940630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18159134" @default.
• W2019940630 hasPublicationYear "2007" @default.
• W2019940630 type Work @default.
• W2019940630 sameAs 2019940630 @default.
• W2019940630 citedByCount "30" @default.
• W2019940630 countsByYear W20199406302012 @default.
• W2019940630 countsByYear W20199406302013 @default.
• W2019940630 countsByYear W20199406302014 @default.
• W2019940630 countsByYear W20199406302015 @default.
• W2019940630 countsByYear W20199406302017 @default.
• W2019940630 countsByYear W20199406302018 @default.
• W2019940630 countsByYear W20199406302019 @default.
• W2019940630 countsByYear W20199406302020 @default.
• W2019940630 countsByYear W20199406302021 @default.
• W2019940630 countsByYear W20199406302022 @default.
• W2019940630 countsByYear W20199406302023 @default.
• W2019940630 crossrefType "journal-article" @default.
• W2019940630 hasAuthorship W2019940630A5000894813 @default.
• W2019940630 hasAuthorship W2019940630A5002075588 @default.
• W2019940630 hasAuthorship W2019940630A5012223457 @default.
• W2019940630 hasAuthorship W2019940630A5017255080 @default.
• W2019940630 hasAuthorship W2019940630A5024904484 @default.
• W2019940630 hasAuthorship W2019940630A5030517670 @default.
• W2019940630 hasAuthorship W2019940630A5030587345 @default.
• W2019940630 hasAuthorship W2019940630A5031155500 @default.
• W2019940630 hasAuthorship W2019940630A5034287641 @default.
• W2019940630 hasAuthorship W2019940630A5037177984 @default.
• W2019940630 hasAuthorship W2019940630A5050855780 @default.
• W2019940630 hasAuthorship W2019940630A5057200745 @default.
• W2019940630 hasAuthorship W2019940630A5058549884 @default.
• W2019940630 hasAuthorship W2019940630A5072348333 @default.
• W2019940630 hasAuthorship W2019940630A5074846489 @default.
• W2019940630 hasAuthorship W2019940630A5079864042 @default.
• W2019940630 hasAuthorship W2019940630A5082354025 @default.
• W2019940630 hasAuthorship W2019940630A5089137663 @default.
• W2019940630 hasAuthorship W2019940630A5089211172 @default.
• W2019940630 hasAuthorship W2019940630A5090846902 @default.
• W2019940630 hasConcept C104317684 @default.
• W2019940630 hasConcept C123584848 @default.
• W2019940630 hasConcept C135763542 @default.
• W2019940630 hasConcept C141231307 @default.
• W2019940630 hasConcept C149011108 @default.
• W2019940630 hasConcept C149904235 @default.
• W2019940630 hasConcept C180754005 @default.
• W2019940630 hasConcept C197754878 @default.
• W2019940630 hasConcept C2776598434 @default.
• W2019940630 hasConcept C2780989783 @default.
• W2019940630 hasConcept C36823959 @default.
• W2019940630 hasConcept C54355233 @default.
• W2019940630 hasConcept C55775858 @default.
• W2019940630 hasConcept C86803240 @default.
• W2019940630 hasConcept C91779695 @default.
• W2019940630 hasConcept C94671646 @default.
• W2019940630 hasConceptScore W2019940630C104317684 @default.

• next