Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019940698> ?p ?o ?g. }
- W2019940698 endingPage "179" @default.
- W2019940698 startingPage "169" @default.
- W2019940698 abstract "The fission yeast Schizosaccharomyces pombe is a highly polarized unicellular eukaryote with two opposite growing poles in which F-actin cytoskeleton is focused. The KIN1/PAR-1/MARK protein family is composed of conserved eukaryotic serine/threonine kinases which are involved in cell polarity, microtubule stability or cell cycle regulation. Here, we investigate the function of the fission yeast KIN1/PAR-1/MARK member, kin1p. Using a deletion allele (kin1Delta), we show that kin1 mutation promotes a delay in septation. Kin1p regulates the structure of the new cell end after cytokinesis by modulating cell wall remodeling. Abnormal shaped interphase kin1Delta cells misplace F-actin patches and the premitotic nucleus. Thus, mitotic kin1Delta cells misposition the F-actin ring assembly site that is dependent on the position of the interphase nucleus. The resulting asymmetric cell division produces daughter cells with distinct shapes. Overexpressed kin1p accumulates asymmetrically at the cell cortex and affects cell shape, F-actin organization and microtubules. Our results suggest that correct dosage of kin1p at the cortex is required for spatial organization of the fission yeast cell." @default.
- W2019940698 created "2016-06-24" @default.
- W2019940698 creator A5022418362 @default.
- W2019940698 creator A5033578678 @default.
- W2019940698 creator A5079936105 @default.
- W2019940698 creator A5080007807 @default.
- W2019940698 date "2004-03-01" @default.
- W2019940698 modified "2023-10-09" @default.
- W2019940698 title "The protein kinase kin1 is required for cellular symmetry in fission yeast" @default.
- W2019940698 cites W1504936161 @default.
- W2019940698 cites W1548424519 @default.
- W2019940698 cites W1566790599 @default.
- W2019940698 cites W1590250492 @default.
- W2019940698 cites W1966398993 @default.
- W2019940698 cites W1986368793 @default.
- W2019940698 cites W1987726850 @default.
- W2019940698 cites W1990265320 @default.
- W2019940698 cites W2001443225 @default.
- W2019940698 cites W2005676334 @default.
- W2019940698 cites W2019068828 @default.
- W2019940698 cites W2021709714 @default.
- W2019940698 cites W2022943167 @default.
- W2019940698 cites W2031824349 @default.
- W2019940698 cites W2034380361 @default.
- W2019940698 cites W2035914909 @default.
- W2019940698 cites W2045960076 @default.
- W2019940698 cites W2051261909 @default.
- W2019940698 cites W2052583991 @default.
- W2019940698 cites W2056452291 @default.
- W2019940698 cites W2057922014 @default.
- W2019940698 cites W2058582467 @default.
- W2019940698 cites W2060006253 @default.
- W2019940698 cites W2060686949 @default.
- W2019940698 cites W2063693682 @default.
- W2019940698 cites W2063826622 @default.
- W2019940698 cites W2069811089 @default.
- W2019940698 cites W2070517400 @default.
- W2019940698 cites W2071330990 @default.
- W2019940698 cites W2080344484 @default.
- W2019940698 cites W2086710990 @default.
- W2019940698 cites W2093849518 @default.
- W2019940698 cites W2097283858 @default.
- W2019940698 cites W2110793252 @default.
- W2019940698 cites W2114835915 @default.
- W2019940698 cites W2118744058 @default.
- W2019940698 cites W2118759548 @default.
- W2019940698 cites W2132088939 @default.
- W2019940698 cites W2132899445 @default.
- W2019940698 cites W2133181593 @default.
- W2019940698 cites W2135051126 @default.
- W2019940698 cites W2149871164 @default.
- W2019940698 cites W2188979715 @default.
- W2019940698 cites W2189435626 @default.
- W2019940698 cites W2194986544 @default.
- W2019940698 cites W2216703381 @default.
- W2019940698 cites W2236011578 @default.
- W2019940698 cites W254598932 @default.
- W2019940698 doi "https://doi.org/10.1016/j.biolcel.2003.12.004" @default.
- W2019940698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15050371" @default.
- W2019940698 hasPublicationYear "2004" @default.
- W2019940698 type Work @default.
- W2019940698 sameAs 2019940698 @default.
- W2019940698 citedByCount "20" @default.
- W2019940698 countsByYear W20199406982012 @default.
- W2019940698 countsByYear W20199406982013 @default.
- W2019940698 countsByYear W20199406982018 @default.
- W2019940698 countsByYear W20199406982019 @default.
- W2019940698 countsByYear W20199406982021 @default.
- W2019940698 crossrefType "journal-article" @default.
- W2019940698 hasAuthorship W2019940698A5022418362 @default.
- W2019940698 hasAuthorship W2019940698A5033578678 @default.
- W2019940698 hasAuthorship W2019940698A5079936105 @default.
- W2019940698 hasAuthorship W2019940698A5080007807 @default.
- W2019940698 hasConcept C125705527 @default.
- W2019940698 hasConcept C142669718 @default.
- W2019940698 hasConcept C1491633281 @default.
- W2019940698 hasConcept C20418707 @default.
- W2019940698 hasConcept C204462481 @default.
- W2019940698 hasConcept C2776519988 @default.
- W2019940698 hasConcept C2777576037 @default.
- W2019940698 hasConcept C2779222958 @default.
- W2019940698 hasConcept C2779429346 @default.
- W2019940698 hasConcept C29452124 @default.
- W2019940698 hasConcept C29537977 @default.
- W2019940698 hasConcept C2993400109 @default.
- W2019940698 hasConcept C3620293 @default.
- W2019940698 hasConcept C45472230 @default.
- W2019940698 hasConcept C47432576 @default.
- W2019940698 hasConcept C49353375 @default.
- W2019940698 hasConcept C54355233 @default.
- W2019940698 hasConcept C70547292 @default.
- W2019940698 hasConcept C85813293 @default.
- W2019940698 hasConcept C86803240 @default.
- W2019940698 hasConcept C93304396 @default.
- W2019940698 hasConcept C95444343 @default.
- W2019940698 hasConceptScore W2019940698C125705527 @default.
- W2019940698 hasConceptScore W2019940698C142669718 @default.
- W2019940698 hasConceptScore W2019940698C1491633281 @default.