FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019941264> ?p ?o ?g. }

• W2019941264 endingPage "139" @default.
• W2019941264 startingPage "135" @default.
• W2019941264 abstract "The molecular mechanisms leading to preeclampsia are poorly understood. It has been related to certain immune mechanisms, as well as the pathological regulation of the renin-angiotensin system together with perturbed salt and plasma volume regulation. Finally, a non-specific, vascular, inflammatory response is generated, which leads to the clinical syndrome. Here, we present novel findings in salt (NaCl) metabolism implying that salt is not only important in blood pressure control and volume homeostasis, but also in immune regulation. Sodium and chloride can be stored without accumulation of water in the interstitium at hypertonic concentrations through interactions with proteoglycans. Macrophages in the interstitium act as osmosensors for salt, producing increased amounts of vascular endothelial factor C, which increases the density of the lymph-capillary network and the production of nitric oxide in vessels. An increased interstitial salt concentration activates the innate immune system, especially Th17 cells, and may be an important trigger for autoimmune diseases. The novel findings with the idea of sodium storage and local mechanisms of volume and immune regulation are appealing for preeclampsia and may unify the immune and vascular hypotheses of preeclampsia." @default.
• W2019941264 created "2016-06-24" @default.
• W2019941264 creator A5011235372 @default.
• W2019941264 creator A5052155693 @default.
• W2019941264 creator A5078018907 @default.
• W2019941264 creator A5079089312 @default.
• W2019941264 creator A5081811761 @default.
• W2019941264 date "2014-03-01" @default.
• W2019941264 modified "2023-09-25" @default.
• W2019941264 title "Novel ideas about salt, blood pressure, and pregnancy" @default.
• W2019941264 cites W1576249624 @default.
• W2019941264 cites W1974170447 @default.
• W2019941264 cites W1975967728 @default.
• W2019941264 cites W1981141937 @default.
• W2019941264 cites W2008295730 @default.
• W2019941264 cites W2017821597 @default.
• W2019941264 cites W2021460176 @default.
• W2019941264 cites W2027156401 @default.
• W2019941264 cites W2035875766 @default.
• W2019941264 cites W2052032860 @default.
• W2019941264 cites W2056691182 @default.
• W2019941264 cites W2063789871 @default.
• W2019941264 cites W2069201443 @default.
• W2019941264 cites W2075684347 @default.
• W2019941264 cites W2085700825 @default.
• W2019941264 cites W2094288280 @default.
• W2019941264 cites W2109901818 @default.
• W2019941264 cites W2115352852 @default.
• W2019941264 cites W2121501744 @default.
• W2019941264 cites W2126992402 @default.
• W2019941264 cites W2143438629 @default.
• W2019941264 cites W2152557975 @default.
• W2019941264 cites W2153210713 @default.
• W2019941264 cites W2153213544 @default.
• W2019941264 cites W2167399827 @default.
• W2019941264 doi "https://doi.org/10.1016/j.jri.2013.04.001" @default.
• W2019941264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23726817" @default.
• W2019941264 hasPublicationYear "2014" @default.
• W2019941264 type Work @default.
• W2019941264 sameAs 2019941264 @default.
• W2019941264 citedByCount "8" @default.
• W2019941264 countsByYear W20199412642013 @default.
• W2019941264 countsByYear W20199412642014 @default.
• W2019941264 countsByYear W20199412642016 @default.
• W2019941264 countsByYear W20199412642017 @default.
• W2019941264 countsByYear W20199412642019 @default.
• W2019941264 countsByYear W20199412642022 @default.
• W2019941264 crossrefType "journal-article" @default.
• W2019941264 hasAuthorship W2019941264A5011235372 @default.
• W2019941264 hasAuthorship W2019941264A5052155693 @default.
• W2019941264 hasAuthorship W2019941264A5078018907 @default.
• W2019941264 hasAuthorship W2019941264A5079089312 @default.
• W2019941264 hasAuthorship W2019941264A5081811761 @default.
• W2019941264 hasConcept C126322002 @default.
• W2019941264 hasConcept C134018914 @default.
• W2019941264 hasConcept C136449434 @default.
• W2019941264 hasConcept C185592680 @default.
• W2019941264 hasConcept C198710026 @default.
• W2019941264 hasConcept C203014093 @default.
• W2019941264 hasConcept C2777218350 @default.
• W2019941264 hasConcept C2779234561 @default.
• W2019941264 hasConcept C519581460 @default.
• W2019941264 hasConcept C54355233 @default.
• W2019941264 hasConcept C63645605 @default.
• W2019941264 hasConcept C71924100 @default.
• W2019941264 hasConcept C84393581 @default.
• W2019941264 hasConcept C86803240 @default.
• W2019941264 hasConcept C8891405 @default.
• W2019941264 hasConcept C95444343 @default.
• W2019941264 hasConceptScore W2019941264C126322002 @default.
• W2019941264 hasConceptScore W2019941264C134018914 @default.
• W2019941264 hasConceptScore W2019941264C136449434 @default.
• W2019941264 hasConceptScore W2019941264C185592680 @default.
• W2019941264 hasConceptScore W2019941264C198710026 @default.
• W2019941264 hasConceptScore W2019941264C203014093 @default.
• W2019941264 hasConceptScore W2019941264C2777218350 @default.
• W2019941264 hasConceptScore W2019941264C2779234561 @default.
• W2019941264 hasConceptScore W2019941264C519581460 @default.
• W2019941264 hasConceptScore W2019941264C54355233 @default.
• W2019941264 hasConceptScore W2019941264C63645605 @default.
• W2019941264 hasConceptScore W2019941264C71924100 @default.
• W2019941264 hasConceptScore W2019941264C84393581 @default.
• W2019941264 hasConceptScore W2019941264C86803240 @default.
• W2019941264 hasConceptScore W2019941264C8891405 @default.
• W2019941264 hasConceptScore W2019941264C95444343 @default.
• W2019941264 hasLocation W20199412641 @default.
• W2019941264 hasLocation W20199412642 @default.
• W2019941264 hasOpenAccess W2019941264 @default.
• W2019941264 hasPrimaryLocation W20199412641 @default.
• W2019941264 hasRelatedWork W1977123261 @default.
• W2019941264 hasRelatedWork W2044747643 @default.
• W2019941264 hasRelatedWork W2047608102 @default.
• W2019941264 hasRelatedWork W2068374317 @default.
• W2019941264 hasRelatedWork W2077998387 @default.
• W2019941264 hasRelatedWork W2088924510 @default.
• W2019941264 hasRelatedWork W2117060894 @default.
• W2019941264 hasRelatedWork W2126797993 @default.
• W2019941264 hasRelatedWork W2418574610 @default.

• next