Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019943019> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2019943019 endingPage "92" @default.
- W2019943019 startingPage "87" @default.
- W2019943019 abstract "Since plasminogen is the proenzyme of plasmin most acquired defects of plasminogen are associated with situations with an increased fibrinolytic activity. Congenital defects also have been described both such associated with thrombotic disease and such that are not. An increased fibrinolytic activity leading to an acquired plasminogen defect is seen 1) in situations complicated with a free proteolytic activity most often involving both the fibrinolytic and the coagulation systems, 2) as a result of locally increased fibrinolytic activity (angiomas), 3) during thrombolytic therapy using plasminogen activators (SK, UK, tPA). A congenital plasminogen defect characterized by 1) a low protein level as well as one with 2) a normal plasminogen protein level in plasma but a defect activation pattern has been reported. Plasminogen can be determined immunochemically, a method which does not differentiate between functionally active plasminogen/plasmin and complexes between these proteins and inhibitors. Plasminogen activity is measured in a chromogenic method using the chromogenic substrate S2251 (Kabi Diagnostica, Stockholm). In this latter method SK is used as a plasminogen activator and the total plasmin formed is measured amidolytically. Using both the immunochemical and the amidolytical methods it has been possible to identify congenital plasminogen defects characterized by a defective activation of plasminogen into plasmin, a defect that has been associated with thromboembolic disease. Another congenital plasminogen defect seems to be caused by a decreased synthesis of a normal plasminogen molecule. Such a defect may not be associated with thrombotic disease. In situations complicated with an increased fibrinolytic activity, decreased plasminogen levels (in both types of assay) are of diagnostic help. Values down to below 50% or even lower may be seen.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2019943019 created "2016-06-24" @default.
- W2019943019 creator A5044453178 @default.
- W2019943019 creator A5085813098 @default.
- W2019943019 date "1988-01-01" @default.
- W2019943019 modified "2023-09-27" @default.
- W2019943019 title "Characterizing Hereditary and Acquired Defects of Plasminogen" @default.
- W2019943019 doi "https://doi.org/10.1159/000215842" @default.
- W2019943019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3280427" @default.
- W2019943019 hasPublicationYear "1988" @default.
- W2019943019 type Work @default.
- W2019943019 sameAs 2019943019 @default.
- W2019943019 citedByCount "1" @default.
- W2019943019 crossrefType "journal-article" @default.
- W2019943019 hasAuthorship W2019943019A5044453178 @default.
- W2019943019 hasAuthorship W2019943019A5085813098 @default.
- W2019943019 hasConcept C126322002 @default.
- W2019943019 hasConcept C128463046 @default.
- W2019943019 hasConcept C181199279 @default.
- W2019943019 hasConcept C185592680 @default.
- W2019943019 hasConcept C203014093 @default.
- W2019943019 hasConcept C2776825266 @default.
- W2019943019 hasConcept C2778382381 @default.
- W2019943019 hasConcept C2779679481 @default.
- W2019943019 hasConcept C2781071845 @default.
- W2019943019 hasConcept C43617362 @default.
- W2019943019 hasConcept C54173615 @default.
- W2019943019 hasConcept C55493867 @default.
- W2019943019 hasConcept C71924100 @default.
- W2019943019 hasConceptScore W2019943019C126322002 @default.
- W2019943019 hasConceptScore W2019943019C128463046 @default.
- W2019943019 hasConceptScore W2019943019C181199279 @default.
- W2019943019 hasConceptScore W2019943019C185592680 @default.
- W2019943019 hasConceptScore W2019943019C203014093 @default.
- W2019943019 hasConceptScore W2019943019C2776825266 @default.
- W2019943019 hasConceptScore W2019943019C2778382381 @default.
- W2019943019 hasConceptScore W2019943019C2779679481 @default.
- W2019943019 hasConceptScore W2019943019C2781071845 @default.
- W2019943019 hasConceptScore W2019943019C43617362 @default.
- W2019943019 hasConceptScore W2019943019C54173615 @default.
- W2019943019 hasConceptScore W2019943019C55493867 @default.
- W2019943019 hasConceptScore W2019943019C71924100 @default.
- W2019943019 hasIssue "1" @default.
- W2019943019 hasLocation W20199430191 @default.
- W2019943019 hasLocation W20199430192 @default.
- W2019943019 hasOpenAccess W2019943019 @default.
- W2019943019 hasPrimaryLocation W20199430191 @default.
- W2019943019 hasRelatedWork W1526535249 @default.
- W2019943019 hasRelatedWork W1992410460 @default.
- W2019943019 hasRelatedWork W2068016443 @default.
- W2019943019 hasRelatedWork W2091313087 @default.
- W2019943019 hasRelatedWork W2166718107 @default.
- W2019943019 hasRelatedWork W2314067290 @default.
- W2019943019 hasRelatedWork W2405335091 @default.
- W2019943019 hasRelatedWork W2414916611 @default.
- W2019943019 hasRelatedWork W2418768116 @default.
- W2019943019 hasRelatedWork W4239469081 @default.
- W2019943019 hasVolume "18" @default.
- W2019943019 isParatext "false" @default.
- W2019943019 isRetracted "false" @default.
- W2019943019 magId "2019943019" @default.
- W2019943019 workType "article" @default.