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• W2019943090 abstract "Microvessels are composed of endothelial cells and surrounding pericytes. Angiogenesis, a neo-vessel formation from pre-existing microvessels, is a complex phenomenon, which requires following sequential steps: detachment of pre-existing pericytes for vascular destabilization, extracellular matrix turnover, migration, proliferation, tube formation by endothelial cells (ECs), and reattachment of pericytes for vascular stabilization. Aminopeptidases regulate the N-terminal modification of proteins and peptides for maturation, activation or degradation, and thereby relate to a variety of biological processes. Recently, three aminopeptidases have been reported to be involved in angiogenesis. They include type 2 methionine aminopeptidase, aminopeptidase N, and adipocyte-derived leucine aminopeptidase/puromycin insensitive leucyl-specific aminopeptidase. This review will focus on the possible role of these aminopeptideses in angiogenesis." @default.
• W2019943090 created "2016-06-24" @default.
• W2019943090 creator A5050198503 @default.
• W2019943090 date "2004-01-01" @default.
• W2019943090 modified "2023-09-27" @default.
• W2019943090 title "Role of Aminopeptidase in Angiogenesis" @default.
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• W2019943090 doi "https://doi.org/10.1248/bpb.27.772" @default.
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