Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019943399> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2019943399 endingPage "227" @default.
- W2019943399 startingPage "227" @default.
- W2019943399 abstract "The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the etiology or treatment of so many medical problems, including anxiety, depression, obsessive-compulsive disorder, schizophrenia, hypertension, stroke, migraine, and nausea. This chapter discusses the recent advancement in the research of serotonin. The 5-HT1 receptor is a high affinity binding site and is divided into four subgroups. In the central nervous system (CNS), the 5-HT1A receptor is broadly distributed, occurring as a somaldodendritic autoreceptor on 5-HT neurons. The 5-HT1A receptor has been widely implicated in anxiety and depression. The 8-OH-DPAT is the prototypical 5-HT1A agonist and in its radiolabeled form is used to characterize the 5-HT1A receptor. A growing body of evidence indicates that compounds in the arylpiperazine class have anxiolytic and antidepressant properties in humans. This effect is thought to be mediated by an inhibitory action on neurons and not simply a result of agonist induced hypothermia. Selective 5-HT1A antagonist remains elusive. While not selective, the most commonly used 5-HT1A antagonists are spiperone, propranolol, and pindolol. Although the 5-HT1B receptor is found in rats and mice, its presence has not been demonstrated in humans. Most agents that bind at the 5-HT1C receptor also bind at 5-HT2 receptors. Although it is not selective, ketanserin is the prototypical 5-HT2 receptor antagonist. There has been a longstanding interest in 5-HT2 antagonists for the prophylactic treatment of migraine. Despite the large amount of research aimed at discovering 5-HT3 receptor ligands, selective ligands have only recently become available. A large number of compounds have been prepared that bind at the 5-HT3 receptor as antagonists. Many of these compounds are clinically effective in reducing the nausea caused by radiation and chemotherapy cancer treatments." @default.
- W2019943399 created "2016-06-24" @default.
- W2019943399 creator A5007856961 @default.
- W2019943399 creator A5021231531 @default.
- W2019943399 creator A5027074814 @default.
- W2019943399 date "1993-04-01" @default.
- W2019943399 modified "2023-09-27" @default.
- W2019943399 title "Clozapine, risperidone and spiperone prefer distinct domains of the 5-HT2 serotonin receptor for high affinity binding" @default.
- W2019943399 doi "https://doi.org/10.1016/0920-9964(93)90498-8" @default.
- W2019943399 hasPublicationYear "1993" @default.
- W2019943399 type Work @default.
- W2019943399 sameAs 2019943399 @default.
- W2019943399 citedByCount "0" @default.
- W2019943399 crossrefType "journal-article" @default.
- W2019943399 hasAuthorship W2019943399A5007856961 @default.
- W2019943399 hasAuthorship W2019943399A5021231531 @default.
- W2019943399 hasAuthorship W2019943399A5027074814 @default.
- W2019943399 hasConcept C126322002 @default.
- W2019943399 hasConcept C126855140 @default.
- W2019943399 hasConcept C15744967 @default.
- W2019943399 hasConcept C169760540 @default.
- W2019943399 hasConcept C170493617 @default.
- W2019943399 hasConcept C172773627 @default.
- W2019943399 hasConcept C200220013 @default.
- W2019943399 hasConcept C2775864247 @default.
- W2019943399 hasConcept C2777785214 @default.
- W2019943399 hasConcept C2778938600 @default.
- W2019943399 hasConcept C2781073084 @default.
- W2019943399 hasConcept C2781093953 @default.
- W2019943399 hasConcept C53910766 @default.
- W2019943399 hasConcept C71924100 @default.
- W2019943399 hasConcept C86803240 @default.
- W2019943399 hasConcept C98274493 @default.
- W2019943399 hasConceptScore W2019943399C126322002 @default.
- W2019943399 hasConceptScore W2019943399C126855140 @default.
- W2019943399 hasConceptScore W2019943399C15744967 @default.
- W2019943399 hasConceptScore W2019943399C169760540 @default.
- W2019943399 hasConceptScore W2019943399C170493617 @default.
- W2019943399 hasConceptScore W2019943399C172773627 @default.
- W2019943399 hasConceptScore W2019943399C200220013 @default.
- W2019943399 hasConceptScore W2019943399C2775864247 @default.
- W2019943399 hasConceptScore W2019943399C2777785214 @default.
- W2019943399 hasConceptScore W2019943399C2778938600 @default.
- W2019943399 hasConceptScore W2019943399C2781073084 @default.
- W2019943399 hasConceptScore W2019943399C2781093953 @default.
- W2019943399 hasConceptScore W2019943399C53910766 @default.
- W2019943399 hasConceptScore W2019943399C71924100 @default.
- W2019943399 hasConceptScore W2019943399C86803240 @default.
- W2019943399 hasConceptScore W2019943399C98274493 @default.
- W2019943399 hasIssue "2-3" @default.
- W2019943399 hasLocation W20199433991 @default.
- W2019943399 hasOpenAccess W2019943399 @default.
- W2019943399 hasPrimaryLocation W20199433991 @default.
- W2019943399 hasRelatedWork W2003847756 @default.
- W2019943399 hasRelatedWork W2011772285 @default.
- W2019943399 hasRelatedWork W2019365375 @default.
- W2019943399 hasRelatedWork W2024368316 @default.
- W2019943399 hasRelatedWork W2048755882 @default.
- W2019943399 hasRelatedWork W2052350817 @default.
- W2019943399 hasRelatedWork W2057313421 @default.
- W2019943399 hasRelatedWork W2063823259 @default.
- W2019943399 hasRelatedWork W4233599398 @default.
- W2019943399 hasRelatedWork W1998713329 @default.
- W2019943399 hasVolume "9" @default.
- W2019943399 isParatext "false" @default.
- W2019943399 isRetracted "false" @default.
- W2019943399 magId "2019943399" @default.
- W2019943399 workType "article" @default.