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- W2019946667 abstract "ethanol (1 g/kg) or WIN 55,212-2 was administered for 5 days, from PND 28 to PND 32. Such early ethanol exposure decreased (−28% p< 0.05) spontaneous alcohol consumption at adulthood. In contrast, their spontaneous alcohol intake increased (+37% p< 0.05) when C57BL/6J mice had been treated with WIN 55,212-2 at adolescence. In DBA/2J mice, which spontaneously avoid alcohol at adult age, the latter treatment did not significantly affect this behavioural trait. In contrast, early alcohol intake at adolescence regularly increased their spontaneous alcohol consumption under free-choice conditions at adulthood. This augmentation ranged between +34% and +94% (p< 0.001), depending on the dose and duration of early ethanol administration. No changes in 5-HT1A G protein coupling efficacy were generally observed in animals which had been exposed to alcohol at adolescence, except in C57BL/6J mice with an induced decrease in alcohol intake at adulthood (see above) for which 5-carboxamidotryptamine exhibited a 3-fold increased potency (p< 0.05) to enhance [35S]GTP-g-S binding in the hippocampus. These results show that early ethanol and/or cannabis consumption can affect ethanol preference at adulthood. The differences between C57BL/6J and DBA/2J mice indicate that such induced modulations of alcohol intake are under genetic control. The change in 5-HT1A receptor coupling suggests that the critical influence of gene– environment interactions on alcohol preference/avoidance at adulthood may depend-in part-on serotoninergic mechanisms. This research has been supported by grants from INSERM, IREB and MILDT." @default.
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- W2019946667 date "2009-03-01" @default.
- W2019946667 modified "2023-09-27" @default.
- W2019946667 title "P.4.11 Higher histamine synthesis and release in inbred Roman high versus low avoidance rats: a histaminergic hypothesis" @default.
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- W2019946667 doi "https://doi.org/10.1016/s0924-977x(09)70101-4" @default.
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